Impact of very old age on the expression of cervical spinal cord cell markers in rats.
Impact of very old age on the expression of cervical spinal cord cell markers in rats.
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DOI：
10.1016/j.jchemneu.2008.11.001
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发表时间：
2009-03
影响因子：
2.8
通讯作者：
Portiansky EL
中科院分区：
文献类型：
--
作者：
Fontana PA;Barbeito CG;Goya RG;Gimeno EJ;Portiansky EL
衰老是一个与一些细胞标记物的解剖变化和表达丧失相关的过程。已知中间纤维赋予细胞和组织机械稳定性。其中一些存在于中枢神经系统的不同细胞群中。为了探索极端年龄的影响，我们以幼龄大鼠（5个月）为参照，用免疫组织化学方法表征了非常高龄大鼠（28个月）颈脊髓灰质细胞中中间丝和其他细胞标志物的变化。老龄大鼠脊髓重量（12.6±1.1 g）显著高于幼龄大鼠（8.4±1.1 g） （P < 0.001）。脊髓长度也随年龄的增加而显著增加（青年7.9±0.3 cm，老年8.28±0.1 cm） （P < 0.05）。老年大鼠的神经丝染色面积和密度均较幼鼠增加。颈椎节段平均面积随年龄增加有显著性差异（P < 0.05）。随着年龄的增长，室管膜区Vimentin的表达面积和强度均有所下降。我们的数据显示，老年大鼠颈脊髓的形态和组织化学模式发生了一些明显的变化。然而，它们并不一定代表病理情况，而是可能反映可塑性重组。
Aging is a process associated with both anatomical changes and loss of expression of some cell markers. Intermediate filaments are known to impart mechanical stability to cells and tissues. Some of them are present in different cell populations of the central nervous system. In order to explore the impact of extreme age we immunohistochemically characterized the changes in intermediate filaments and other cellular markers present in cells populating the gray matter cervical spinal cord of very old rats (28 months) taking young (5 months) counterparts as a reference. The spinal cord weight of the senile animals (12.6 ± 1.1 g) was significantly higher (P < 0.001) than that of the young animals (8.4 ± 1.1 g). Spinal cord length also increased significantly (P < 0.05) with age (7.9 ± 0.3 cm vs. 8.28 ± 0.1 cm for young and senile, respectively). An increase in both neurofilament staining area and density was observed in senile rats in comparison to young animals. A significant (P < 0.05) age-related increment in the mean area of the cervical segments was observed. Vimentin expression in the ependymal zone decreased in area and intensity during aging. Our data show that there are some significant changes in the morphological and histochemical patterns of the cervical spinal cord in senile rats. However, they do not necessarily represent a pathologic situation and may rather reflect plastic reorganization.
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影响因子：
4.4
作者：
Perez de Heredia, Fatima;Larque, Elvira;Garaulet, Marta
通讯作者：
Garaulet, Marta
影响因子：
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作者：
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Keast, Janet R.
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KAWASAKI, K
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3.4
作者：
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通讯作者：
Vincent M
影响因子：
3.1
作者：
Chiasson, Keith;Lahaie-Collins, Vicky;Martinoli, Maria-Grazia
通讯作者：
Martinoli, Maria-Grazia