Enzymatic biosensors based on the use of metal oxide nanoparticles

Enzymatic biosensors based on the use of metal oxide nanoparticles
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基于金属氧化物纳米粒子的酶生物传感器

DOI:
10.1007/s00604-013-1069-5
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发表时间:
2014-03
期刊:
影响因子:
5.7
通讯作者:
Xian, Yuezhong
Xian, Yuezhong
中科院分区:
化学2区
文献类型:
--
作者:
Li, Bingyu;Chen, Ningning;Zhao, Kai;Xian, Yuezhong

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在过去的几十年中,已经开发了各种技术来获得纳米级的材料,以设计具有高灵敏度,选择性和效率的生物传感器。金属氧化物纳米颗粒(MONP)由于其独特的物理、化学和催化性能而受到人们的特别关注。本文综述了基于MONP的酶生物传感器的研究进展。综述了MONP的合成方法、固定化策略及其在酶生物传感系统中的作用。文章被细分为基于(a)氧化锌纳米颗粒、(B)氧化钛纳米颗粒、(c)氧化铁纳米颗粒和(d)其他金属氧化物纳米颗粒的酶生物传感器的部分。虽然基于MONP的酶生物传感器已经取得了实质性的进展,但它们在真实的样品中的应用仍然存在,因为必须解决诸如再现性和传感器稳定性等问题。参考文献256篇。图对基于金属氧化物纳米颗粒(MONP)的酶生物传感器进行了全面的评述。对基于MONP的酶生物传感系统的研究进展和发展前景进行了讨论。
Over the past decades, various techniques have been developed to obtain materials at a nanoscale level to design biosensors with high sensitivity, selectivity and efficiency. Metal oxide nanoparticles (MONPs) are of particular interests and have received much attention because of their unique physical, chemical and catalytic properties. This review summarizes the progress made in enzymatic biosensors based on the use of MONPs. Synthetic methods, strategies for immobilization, and the functions of MONPs in enzymatic biosensing systems are reviewed and discussed. The article is subdivided into sections on enzymatic biosensors based on (a) zinc oxide nanoparticles, (b) titanium oxide nanoparticles, (c) iron oxide nanoparticles, and (d) other metal oxide nanoparticles. While substantial advances have been made in MONPs-based enzymatic biosensors, their applications to real samples still lie ahead because issues such as reproducibility and sensor stability have to be solved. The article contains 256 references.FigureA comprehensive and critical review on enzymatic biosensor based on metal oxide nanoparticles (MONPs) was provided. The progress and future perspectives of MONPs based enzymatic biosensing system were discussed.
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