Binaural response properties of low-frequency neurons in the gerbil dorsal nucleus of the lateral lemniscus.
Binaural response properties of low-frequency neurons in the gerbil dorsal nucleus of the lateral lemniscus.
复制标题
沙鼠外侧丘系背核低频神经元的双耳响应特性。
DOI：
10.1152/jn.00713.2005
复制
发表时间：
2006
影响因子：
2.5
通讯作者：
B. Grothe
中科院分区：
文献类型：
--
作者：
I. Siveke;M. Pecka;Armin H. Seidl;S. Baudoux;B. Grothe
声音在双耳的强度和到达时间的差异，耳间强度和时间差（IID，ITD），是声音定位的主要线索。这两种线索最初都是在上级橄榄复合体（SOC）中处理的，该复合体投射到外侧丘系背核（DNLL）和听觉中脑。在这里，我们提出的基本响应特性的低频（< 2 kHz）DNLL神经元和双耳的敏感性ITD和IID在麻醉沙鼠。我们发现许多神经元显示双耳属性类似于SOC神经元的报告。IID特性与对侧外侧上级橄榄（LSO）相似。大多数细胞的ITD敏感性类似于同侧内侧上级橄榄（MSO）或对侧LSO。少数细胞显示中间类型的ITD敏感性。在具有MSO样反应的神经元中，诱发最大放电的ITDs大多在沙土鼠自然经历的ITDs范围之外。然而，其ITD函数的一阶导数的最大值（最陡斜率）完全在ITD的生理范围内。这一发现与ITD的人口概念而不是地方代码一致。此外，我们描述了其他几个双耳特性以及生理和解剖证据的一个小，但重要的输入从对侧MSO。大量ITD敏感的低频神经元暗示了DNLL在ITD加工中的重要作用，并促进了该核团作为进一步研究ITD编码的合适模型。
Differences in intensity and arrival time of sounds at the two ears, interaural intensity and time differences (IID, ITD), are the chief cues for sound localization. Both cues are initially processed in the superior olivary complex (SOC), which projects to the dorsal nucleus of the lateral lemniscus (DNLL) and the auditory midbrain. Here we present basic response properties of low-frequency (< 2 kHz) DNLL neurons and their binaural sensitivity to ITDs and IIDs in the anesthetized gerbil. We found many neurons showing binaural properties similar to those reported for SOC neurons. IID-properties were similar to that of the contralateral lateral superior olive (LSO). A majority of cells had an ITD sensitivity resembling that of either the ipsilateral medial superior olive (MSO) or the contralateral LSO. A smaller number of cells displayed intermediate types of ITD sensitivity. In neurons with MSO-like response ITDs that evoked maximal discharges were mostly outside of the range of ITDs the gerbil naturally experiences. The maxima of the first derivative of their ITD-functions (steepest slope), however, were well within the physiological range of ITDs. This finding is consistent with the concept of a population rather than a place code for ITDs. Moreover, we describe several other binaural properties as well as physiological and anatomical evidence for a small but significant input from the contralateral MSO. The large number of ITD-sensitive low-frequency neurons implicates a substantial role for the DNLL in ITD processing and promotes this nucleus as a suitable model for further studies on ITD-coding.
登录
查看更多内容
沙鼠（Meriones unguiculatus）的声音定位和双耳提示的使用。
影响因子：
1.9
作者：
Heffner,RS;Heffner,HE
通讯作者：
Heffner,HE
影响因子：
2.5
作者：
COVEY, E
通讯作者：
COVEY, E
猫下丘低频神经元的双耳相互作用。
影响因子：
2.5
作者：
Yin,TC;Kuwada,S
通讯作者：
Kuwada,S
猫下丘低频神经元的双耳相互作用。
影响因子：
2.5
作者：
Yin,TC;Kuwada,S
通讯作者：
Kuwada,S
影响因子：
2.5
作者：
Kuwada,S;Yin,TC
通讯作者：
Yin,TC