Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation.
Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation.
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DOI：
10.3390/jcm4020204
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发表时间：
2015
影响因子：
3.9
通讯作者：
Fisher C
中科院分区：
文献类型：
--
作者：
Fisher C
Most human papillomavirus (HPV) antiviral strategies have focused upon inhibiting viral DNA replication, but it is increasingly apparent that viral DNA levels can be chemically controlled by approaches that promote its instability. HPVs and other DNA viruses have a tenuous relationship with their hosts. They must replicate and hide from the DNA damage response (DDR) and innate immune systems, which serve to protect cells from foreign or “non-self” DNA, and yet they draft these same systems to support their life cycles. DNA binding antiviral agents promoting massive viral DNA instability and elimination are reviewed. Mechanistic studies of these agents have identified genetic antiviral enhancers and repressors, antiviral sensitizers, and host cell elements that protect and stabilize HPV genomes. Viral DNA degradation appears to be an important means of controlling HPV DNA levels in some cases, but the underlying mechanisms remain poorly understood. These findings may prove useful not only for understanding viral DNA persistence but only in devising future antiviral strategies.
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影响因子：
64.5
作者：
Buis J;Wu Y;Deng Y;Leddon J;Westfield G;Eckersdorff M;Sekiguchi JM;Chang S;Ferguson DO
通讯作者：
Ferguson DO
DOI：
10.1083/jcb.201204035
发表时间：
2012-08-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Daniel JA;Pellegrini M;Lee BS;Guo Z;Filsuf D;Belkina NV;You Z;Paull TT;Sleckman BP;Feigenbaum L;Nussenzweig A
通讯作者：
Nussenzweig A
影响因子：
1.2
作者：
Archambault J;Melendy T
通讯作者：
Melendy T
影响因子：
5.4
作者：
BEDELL, MA;HUDSON, JB;LAIMINS, LA
通讯作者：
LAIMINS, LA
影响因子：
3.8
作者：
Chouhy, Diego;Bolatti, Elisa M.;Giri, Adriana A.
通讯作者：
Giri, Adriana A.