Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease.
Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease.
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DOI：
10.3389/fncel.2016.00294
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发表时间：
2016
影响因子：
5.3
通讯作者：
Yudowski GA
中科院分区：
文献类型：
--
作者：
Kendall DA;Yudowski GA
20世纪80年代末和90年代初，两种主要的大麻素受体(CB1和CB2)的鉴定和克隆及其内源性配体的发现，为了解内源性大麻系统(ECS)的机制和生理作用做出了重大努力。由于CB1受体在中枢神经系统(CNS)中的表达和定位，及其内源性配体(内源性大麻素(ECB))和参与其合成和降解的酶，参与了从记忆障碍到神经退行性疾病等多种病理生理事件。在这篇综述中，我们将提供ECS的一般概述，重点是CB1受体在健康和疾病中的作用。我们将描述我们目前对受体信号和转运的复杂方面的理解，包括非规范的信号通路，如那些在功能选择性和配体偏爱的背景下由β-arrestins介导的信号通路。最后，我们将重点介绍与CB1受体有关的一些疾病。在过去的30年里，已经取得了重大的知识。然而，仍需要更多的研究来充分了解ECS的复杂作用，特别是在体内，并揭示其作为治疗靶点来源的真正潜力。
The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors together with the discovery of their endogenous ligands in the late 80s and early 90s, resulted in a major effort aimed at understanding the mechanisms and physiological roles of the endocannabinoid system (ECS). Due to its expression and localization in the central nervous system (CNS), the CB1 receptor together with its endogenous ligands (endocannabinoids (eCB)) and the enzymes involved in their synthesis and degradation, has been implicated in multiple pathophysiological events ranging from memory deficits to neurodegenerative disorders among others. In this review, we will provide a general overview of the ECS with emphasis on the CB1 receptor in health and disease. We will describe our current understanding of the complex aspects of receptor signaling and trafficking, including the non-canonical signaling pathways such as those mediated by β-arrestins within the context of functional selectivity and ligand bias. Finally, we will highlight some of the disorders in which CB1 receptors have been implicated. Significant knowledge has been achieved over the last 30 years. However, much more research is still needed to fully understand the complex roles of the ECS, particularly in vivo and to unlock its true potential as a source of therapeutic targets.
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影响因子：
12.4
作者：
Blázquez C;Chiarlone A;Bellocchio L;Resel E;Pruunsild P;García-Rincón D;Sendtner M;Timmusk T;Lutz B;Galve-Roperh I;Guzmán M
通讯作者：
Guzmán M
影响因子：
25
作者：
Dudok, Barna;Barna, Laszlo;Ledri, Marco;Szabo, Szilard I.;Szabadits, Eszter;Pinter, Balazs;Woodhams, Stephen G.;Henstridge, Christopher M.;Balla, Gyula Y.;Nyilas, Rita;Varga, Csaba;Lee, Sang-Hun;Matolcsi, Mate;Cervenak, Judit;Kacskovics, Imre;Watanabe, Masahiko;Sagheddu, Claudia;Melis, Miriam;Pistis, Marco;Soltesz, Ivan;Katona, Istvan
通讯作者：
Katona, Istvan
影响因子：
5.6
作者：
Aso E;Ferrer I
通讯作者：
Ferrer I
影响因子：
5.8
作者：
Bosier, Barbara;Muccioli, Giulio G.;Lambert, Didier M.
通讯作者：
Lambert, Didier M.
DOI：
10.3109/10799893.2014.1003659
发表时间：
2015-02-01
影响因子：
2.8
作者：
Breivogel, Chris S.;Vaghela, Manan S.
通讯作者：
Vaghela, Manan S.