Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic.
Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic.
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DOI：
10.3389/fphar.2014.00037
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发表时间：
2014
影响因子：
5.6
通讯作者：
Ferrer I
中科院分区：
文献类型：
--
作者：
Aso E;Ferrer I
针对阿尔茨海默病（AD）的当前疗法的有限有效性突出了加强致力于开发用于预防或延缓疾病过程的新药剂的研究努力的需要。在过去的几年中，靶向内源性大麻素系统已成为治疗阿尔茨海默病的潜在治疗方法。内源性大麻素系统由许多大麻素受体组成，包括充分表征的CB 1和CB 2受体，以及它们的内源性配体和与这些内源性大麻素化合物的合成和降解相关的酶。几项发现表明，在非精神活性剂量下，天然或合成激动剂对CB 1和CB 2受体的激活通过减少有害的β-淀粉样肽作用和tau磷酸化以及通过促进大脑的内在修复机制，在阿尔茨海默氏症实验模型中具有有益作用。此外，已证明内源性大麻素信号传导调节许多伴随的病理过程，包括神经炎症、兴奋性毒性、线粒体功能障碍和氧化应激。本文总结了主要的实验研究，证明大麻素化合物的多价特性，用于治疗AD，共同鼓励进展的临床试验。
The limited effectiveness of current therapies against Alzheimer’s disease (AD) highlights the need for intensifying research efforts devoted to developing new agents for preventing or retarding the disease process. During the last few years, targeting the endogenous cannabinoid system has emerged as a potential therapeutic approach to treat Alzheimer. The endocannabinoid system is composed by a number of cannabinoid receptors, including the well-characterized CB1 and CB2 receptors, with their endogenous ligands and the enzymes related to the synthesis and degradation of these endocannabinoid compounds. Several findings indicate that the activation of both CB1 and CB2 receptors by natural or synthetic agonists, at non-psychoactive doses, have beneficial effects in Alzheimer experimental models by reducing the harmful β-amyloid peptide action and tau phosphorylation, as well as by promoting the brain’s intrinsic repair mechanisms. Moreover, endocannabinoid signaling has been demonstrated to modulate numerous concomitant pathological processes, including neuroinflammation, excitotoxicity, mitochondrial dysfunction, and oxidative stress. The present paper summarizes the main experimental studies demonstrating the polyvalent properties of cannabinoid compounds for the treatment of AD, which together encourage progress toward a clinical trial.
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影响因子：
2.1
作者：
Chen, B.;Bromley-Brits, K.;Song, W.
通讯作者：
Song, W.
DOI：
10.1196/annals.1432.037
发表时间：
2008-01-01
期刊：
DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES
影响因子：
--
作者：
Brusco, A.;Tagliaferro, P. A.;Onaivi, E. S.
通讯作者：
Onaivi, E. S.
影响因子：
64.5
作者：
Chen R;Zhang J;Fan N;Teng ZQ;Wu Y;Yang H;Tang YP;Sun H;Song Y;Chen C
通讯作者：
Chen C
影响因子：
4
作者：
Aso, Ester;Palomer, Ernest;Ferrer, Isidro
通讯作者：
Ferrer, Isidro
影响因子：
3.7
作者：
D'Addario, Claudio;Di Francesco, Andrea;Maccarrone, Mauro
通讯作者：
Maccarrone, Mauro