Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review.
Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review.
复制标题
小鼠敲除盆腔器官脱垂模型：系统综述。
DOI：
10.1007/s00192-021-05066-5
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发表时间：
2022-07
影响因子：
1.8
通讯作者：
Damaser, Margot S.
中科院分区：
文献类型：
--
作者：
Allen-Brady, Kristina;Bortolini, Maria A. T.;Damaser, Margot S.
盆腔器官脱垂（POP）的小鼠敲除（KO）模型为结缔组织缺陷的作用提供了机制证据，特别是弹性基质重塑受损。我们的目的是总结现有的哪些盆腔器官脱垂小鼠敲除模型可用，以及我们从这些小鼠模型中了解到盆腔器官脱垂发展的病理生理机制有哪些。
我们进行了一项系统综述，并根据PRISMA指南报告了叙述性研究结果。两名独立的评审员在2000年1月1日至2021年3月31日期间，在PubMed、Scopus和Embase中搜索相关的手稿以及会议摘要。会议摘要仅限于过去5年。
搜索策略共得到294个标题。我们最终纳入了25篇文章以及另外11篇会议摘要。已经研究了5种敲除模型：Loxl1、Fbln5、Fbln3、Hoxa11和Upii - sv40t。Loxl1和Fbln5敲除模型提供了最可靠和可预测的盆腔器官脱垂表型。Loxl1敲除小鼠主要因分娩后愈合失败而发生盆腔器官脱垂，而Fbln5敲除小鼠随着年龄增长发生盆腔器官脱垂。这些小鼠敲除模型已被用于各种各样的研究，包括盆腔器官脱垂发展所涉及的遗传途径、盆底的生物力学特性、弹性纤维沉积、盆腔器官脱垂的治疗以及与补片并发症相关的病理生理学。
小鼠敲除模型已被证明是研究特定基因及其在盆腔器官脱垂发生和发展中的作用的一种有价值的工具。它们可能有助于研究盆腔器官脱垂的治疗和盆腔器官脱垂的并发症。
Mouse knockout (KO) models of pelvic organ prolapse (POP) have contributed mechanistic evidence for the role of connective tissue defects, specifically impaired elastic matrix remodeling. Our objective was to summarize what mouse KO models for POP are available and what have we learned from these mouse models about the pathophysiological mechanisms of POP development. We conducted a systematic review and reported narrative findings according to PRISMA guidelines. Two independent reviewers searched PubMed, Scopus and Embase for relevant manuscripts and conference abstracts for the time frame of January 1, 2000, to March 31, 2021. Conference abstracts were limited to the past 5 years. The search strategy resulted in 294 total titles. We ultimately included 25 articles and an additional 11 conference abstracts. Five KO models have been studied: Loxl1, Fbln5, Fbln3, Hoxa11 and Upii-sv40t. Loxl1 and Fbln5 KO models have provided the most reliable and predictable POP phenotype. Loxl1 KO mice develop POP primarily from failure to heal after giving birth, whereas Fbln5 KO mice develop POP with aging. These mouse KO models have been used for a wide variety of investigations including genetic pathways involved in development of POP, biomechanical properties of the pelvic floor, elastic fiber deposition, POP therapies and the pathophysiology associated with mesh complications. Mouse KO models have proved to be a valuable tool in the study of specific genes and their role in the development and progression of POP. They may be useful to study POP treatments and POP complications.
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影响因子：
9.8
作者：
Allen-Brady, Kristina;Norton, Peggy A.;Cannon-Albright, Lisa A.
通讯作者：
Cannon-Albright, Lisa A.
影响因子：
15.9
作者：
Connell, Kathleen A.;Guess, Marsha K.;Taylor, Hugh S.
通讯作者：
Taylor, Hugh S.
影响因子：
1.8
作者：
Abulaizi, Aibibuhan;Abula, Abudoureyimu;Zhakeer, Adilai
通讯作者：
Zhakeer, Adilai
DOI：
10.1590/1806-9282.66.5.680
发表时间：
2020-05-01
期刊：
Revista da Associação Médica Brasileira
影响因子：
--
作者：
Paula, Marcus Vinicius Barbosa de;Lira Júnior, Marcos Antônio de Farias;Oliveira, Emerson de
通讯作者：
Oliveira, Emerson de
影响因子：
3.6
作者：
Borazjani, Ali;Couri, Bruna M.;Damaser, Margot S.
通讯作者：
Damaser, Margot S.