Core promoters are predicted by their distinct physicochemical properties in the genome of Plasmodium falciparum.
Core promoters are predicted by their distinct physicochemical properties in the genome of Plasmodium falciparum.
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DOI:
10.1186/gb-2008-9-12-r178
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发表时间:
2008
期刊:
影响因子:
12.3
通讯作者:
Pizzi, Elisabetta
中科院分区:
文献类型:
--
作者:
Brick, Kevin;Watanabe, Junichi;Pizzi, Elisabetta
A method is presented to computationally identify core promoters in the Plasmodium falciparum genome using only DNA physicochemical properties. Little is known about the structure and distinguishing features of core promoters in Plasmodium falciparum. In this work, we describe the first method to computationally identify core promoters in this AT-rich genome. This prediction algorithm uses solely DNA physicochemical properties as descriptors. Our results add to a growing body of evidence that a physicochemical code for eukaryotic genomes plays a crucial role in core promoter recognition.
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