Immunohistochemical study of caveolin-1 and -2 in the rat retina.

Immunohistochemical study of caveolin-1 and -2 in the rat retina.
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DOI:
10.4142/jvs.2006.7.2.101
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发表时间:
2006-06
影响因子:
1.8
通讯作者:
Shin T
Shin T
中科院分区:
农林科学4区
文献类型:
--
作者:
Kim H;Lee T;Lee J;Ahn M;Moon C;Wie MB;Shin T

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检查视网膜中小窝蛋白-1和-2的表达; Western印迹分析显示两者都存在。免疫组化结果显示,Caveolin-1在视网膜神经节细胞层、内丛状层、外丛状层和血管内皮细胞中均有表达。小窝蛋白-2主要在血管中免疫染色,但也在一些其他元素中。这是首次证实小窝蛋白在大鼠视网膜中的差异表达,提示小窝蛋白在神经胶质细胞和神经元细胞的信号转导中起重要作用。
The expression of caveolin-1 and -2 in the retina was examined; Western blot analysis showed that both were present. Immunohistochemistry indicated that caveolin-1 was expressed in the majority of retinal layers, including the ganglion cell layer, inner plexiform layer, outer plexiform layer, and in the vascular endothelial cells of the retina. Caveolin-2 was primarily immunostained in the vessels, but in a few other elements as well. This is the first demonstration of caveolin differential expression in the retina of rats, and suggests that caveolin plays an important role in signal transduction in glial cells and neuronal cells.
DOI: 10.1006/bbrc.1998.9790
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