Aptamer-based biosensors for detection of lead(II) ion: a review

Aptamer-based biosensors for detection of lead(II) ion: a review
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用于检测铅(II)离子的基于适体的生物传感器:综述

DOI:
10.1039/c7ay00477j
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发表时间:
2017-03
期刊:
影响因子:
3.1
通讯作者:
Tang Lin
Tang Lin
中科院分区:
化学3区
文献类型:
--
作者:
Yang Danxing;Liu Xiaocheng;Zhou Yaoyu;Luo Lin;Zhang Jiachao;Huang Anqi;Mao Qiming;Chen Xiao;Tang Lin

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铅(II)离子(Pb2+)污染可沿食物链沿着累积并对公众健康造成严重威胁。因此,大量的研究工作一直致力于发展快速,灵敏和选择性的生物传感器监测Pb 2+。适体特别是基于Pb2+的DNA酶(通过体外选择从大的DNA文库获得)和DNA分子对许多金属离子具有高度选择性。因此,基于适体的生物传感器已被广泛研究用于具有高灵敏度的Pb2+离子检测。本文主要从荧光传感器、比色传感器和电化学传感器三个方面对Pb2+适体传感器的研究进展进行了综述。
Lead(II) ion (Pb2+) contamination can be accumulated along the food chain and cause a serious threat to public health. Plenty of research effort has thus been devoted to the development of fast, sensitive and selective biosensors for monitoring Pb2+. Aptamer especially Pb2+ based DNAzymes (obtained from a large DNA library via in vitro selection) and DNA molecules are highly selective for a number of metal ions. Therefore, aptamer-based biosensors have been extensively studied for Pb2+ ion detection with a high sensitivity. In this review, we explain the current progress of Pb2+ aptamer-based sensors mainly in three groups: fluorescent; colorimetric; and electrochemical biosensors.
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