Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus.
Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus.
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LupusQoL-China 用于评估中国系统性红斑狼疮患者健康相关生活质量的有效性
DOI：
10.1371/journal.pone.0063795
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lu LJ
中科院分区：
文献类型：
--
作者：
Wang SL;Wu B;Leng L;Bucala R;Lu LJ
目的 调整和评估 LupusQoL 用于中国系统性红斑狼疮 (SLE) 患者的有效性和可靠性。方法 通过对 SLE 受试者的访谈总结来指导该工具的语言修改。适应过程按照LupusQoL-China的指南和预测试结果进行。 220 名 SLE 患者完成了 LupusQoL-China 和基于偏好的通用健康 EuroQoL 量表 (EQ-5D)，其中 20 名患者在 2 周后重复了这些测试。检查了内部一致性（ICR）和重测（TRT）可靠性、收敛效度和判别效度。进行因子分析和Rasch分析。结果 208 名 SLE 受试者的平均 (SD) 年龄为 33.93 (±9.19) 岁。八个域的 ICR 和 TRT 范围分别为 0.811 至 0.965 和 0.836 至 0.974。与 EQ-5D 上的同等领域（身体健康和日常活动 r = −0.63、疼痛和疼痛/不适 r = −0.778、情绪健康和焦虑/抑郁 r = −0.761、计划和日常活动 r = −0.560）相比，LupusQoL-China 领域显示了构建有效性的大量证据。大多数 LupusQoL-China 域可以区分具有不同疾病活动度和终末器官损伤的患者（根据 SELENA-SLEDAI 和 SLICC-DI）。主成分分析揭示了六个因素，验证性因素分析结果与八因素模型类似。结论 这些结果证明 LupusQoL-China 作为中国 SLE 患者的疾病特异性 HRQoL 评估工具是有效的。
Objectives To adapt and assess the validity and reliability of LupusQoL for use in Chinese patients with systemic lupus erythematosus (SLE). Methods Debriefing interviews of subjects with SLE guided the language modifications of the tool. The process of adaptation proceeded according to the guideline and pre-testing results of LupusQoL-China. 220 SLE patients completed LupusQoL-China and a generic preference-based measurement of health EuroQoL scale (EQ-5D), and 20 patients repeated them after 2 weeks. Internal consistency (ICR) and test-retest (TRT) reliability, convergent and discriminant validity were examined. Factor analysis and Rasch analysis were performed. Results The mean (SD) age of the 208 subjects with SLE was 33.93 (±9.19) years. ICR and TRT of the eight domains ranged from 0.811 to 0.965 and 0.836 to 0.974, respectively. The LupusQoL-China domains demonstrated substantial evidence of construct validity when compared with equivalent domains on the EQ-5D (physical health and usual activities r = −0.63, pain and pain/discomfort r = −0.778, emotional health and anxiety/depression r = −0.761, planning and usual activities r = −0.560). Most LupusQoL-China domains could discriminate patients with varied disease activities and end-organ damage (according to SELENA-SLEDAI and SLICC-DI). The principal component analysis revealed six factors, and confirmatory factor analysis result of which is similar to eight factors model. Conclusions These results provide evidence that the LupusQoL-China is valid as a disease-specific HRQoL assessment tool for Chinese patients with SLE.
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