Integrated probabilistic risk assessment for nanoparticles: the case of nanosilica in food.
Integrated probabilistic risk assessment for nanoparticles: the case of nanosilica in food.
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DOI：
10.1007/s11051-015-2911-y
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发表时间：
2015
影响因子：
2.5
通讯作者：
ter Braak, Cajo J. F.
中科院分区：
文献类型：
--
作者：
Jacobs, Rianne;van der Voet, Hilko;ter Braak, Cajo J. F.
深入了解纳米技术和纳米粒子使用的风险是社会接受和安全使用纳米技术的必要条件。纳米颗粒风险评估面临的问题之一是缺乏数据，导致风险评估的不确定性。我们试图通过将先前对食品中纳米二氧化硅（5-200 nm）的确定性研究扩展为完全集成的概率风险评估来量化这种不确定性。我们使用综合概率风险评估方法，其中统计分布和自助方法被用来量化风险评估中的不确定性和可变性。由于存在大量的不确定性，这种概率方法将可变性与不确定性分开，有助于更好地理解风险评估。我们发现，相对于确定性研究的结果，量化不确定性并没有增加感知风险。我们指出了危害特性的某些方面，这些方面对风险评估中的总不确定性贡献最大，这表明进一步的研究将从获得有关这些方面的更可靠数据中获益最多。本文的在线版本（doi：10.1007/s11051-015-2911-y）包含补充材料，可供授权用户使用。
Insight into risks of nanotechnology and the use of nanoparticles is an essential condition for the social acceptance and safe use of nanotechnology. One of the problems with which the risk assessment of nanoparticles is faced is the lack of data, resulting in uncertainty in the risk assessment. We attempt to quantify some of this uncertainty by expanding a previous deterministic study on nanosilica (5–200 nm) in food into a fully integrated probabilistic risk assessment. We use the integrated probabilistic risk assessment method in which statistical distributions and bootstrap methods are used to quantify uncertainty and variability in the risk assessment. Due to the large amount of uncertainty present, this probabilistic method, which separates variability from uncertainty, contributed to a better understandable risk assessment. We found that quantifying the uncertainties did not increase the perceived risk relative to the outcome of the deterministic study. We pinpointed particular aspects of the hazard characterization that contributed most to the total uncertainty in the risk assessment, suggesting that further research would benefit most from obtaining more reliable data on those aspects. The online version of this article (doi:10.1007/s11051-015-2911-y) contains supplementary material, which is available to authorized users.
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