Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores.
Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores.
复制标题
DOI：
10.1007/s10803-013-2013-6
复制
发表时间：
2015-07
影响因子：
3.9
通讯作者：
Abbeduto, Leonard
中科院分区：
文献类型：
--
作者：
McDuffie, Andrea;Thurman, Angela John;Hagerman, Randi J.;Abbeduto, Leonard
自闭症的症状在男性脆性X综合征（FXS）中很常见，但尚不清楚症状特征是否与非综合征型ASD不同。使用孤独症诊断量表修订版（ADI-R）的单项评分，我们检查了FXS男孩与非综合征型ASD同龄男孩的当前孤独症症状差异。此外，参与者的不同子样本在自闭症诊断状态和自闭症症状的严重程度上相匹配。组间比较显示，与年龄、诊断和严重程度相匹配的非综合征型ASD男孩相比，FXS男孩在社交微笑方面表现出明显更少的损伤。严重程度匹配的FXS男孩比非综合征ASD男孩表现出更多的复杂行为障碍。FXS和非综合征型ASD之间的行为差异可能在理解FXS中ASD的原因和相关性以及开发和实施适当的治疗方面具有理论重要性。
Symptoms of autism are frequent in males with fragile X syndrome (FXS), but it is not clear whether symptom profiles differ from those of nonsyndromic ASD. Using individual item scores from the Autism Diagnostic Inventory-Revised (ADI-R), we examined which current symptoms of autism differed in boys with FXS relative to same-aged boys diagnosed with nonsyndromic ASD. In addition, different subsamples of participants were matched on autism diagnostic status and severity of autism symptoms. Between-group comparisons revealed that boys with FXS showed significantly less impairment in Social Smiling than did age-, diagnostic, and severity-matched boys with nonsyndromic ASD. Severity-matched boys with FXS showed more impairment in Complex Mannerisms than did boys with nonsyndromic ASD. Behavioral differences between FXS and nonsyndromic ASD may be of theoretical importance in understanding the causes and correlates of ASD in FXS and in developing and implementing appropriate treatments.
登录
查看更多内容
影响因子：
3.9
作者：
Gotham, Katherine;Pickles, Andrew;Lord, Catherine
通讯作者：
Lord, Catherine
DOI：
10.1007/978-3-642-21649-7_17
发表时间：
2012-01-01
期刊：
MODELING FRAGILE X SYNDROME
影响因子：
--
作者：
Hagerman, Randi;Lauterborn, Julie;Berry-Kravis, Elizabeth
通讯作者：
Berry-Kravis, Elizabeth
影响因子：
2
作者：
Hernandez, R. Nick;Feinberg, Rachel L.;Vaurio, Rebecca;Passanante, Natalie M.;Thompson, Richard E.;Kaufmann, Walter E.
通讯作者：
Kaufmann, Walter E.
影响因子：
25
作者：
Belmonte, Matthew K.;Bourgeron, Thomas
通讯作者：
Bourgeron, Thomas
影响因子：
13.9
作者：
Bhakar AL;Dölen G;Bear MF
通讯作者：
Bear MF