Standardizing ADOS scores for a measure of severity in autism spectrum disorders.

Standardizing ADOS scores for a measure of severity in autism spectrum disorders.
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DOI:
10.1007/s10803-008-0674-3
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发表时间:
2009-05
影响因子:
3.9
通讯作者:
Lord, Catherine
Lord, Catherine
中科院分区:
心理学3区
文献类型:
--
作者:
Gotham, Katherine;Pickles, Andrew;Lord, Catherine

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本研究的目的是在一个大样本中标准化自闭症诊断观察表(ADOS)评分,以近似自闭症严重程度度量。使用1415名2-16岁自闭症谱系障碍(ASD)或非谱系诊断的个体的数据集,将来自1118名ASD个体的1807项评估的子集划分为狭窄的年龄和语言细胞。在每个单元格内,严重程度评分基于对应于每个ADOS诊断分类的原始总数的百分比。校准的严重程度评分在发育组中分布更均匀,受参与者人口统计学的影响比原始总数小。这个指标应该是有用的,在比较评估跨模块和时间,并确定自闭症严重程度的临床,遗传和神经生物学研究的轨迹。
The aim of this study is to standardize Autism Diagnostic Observation Schedule (ADOS) scores within a large sample to approximate an autism severity metric. Using a dataset of 1415 individuals aged 2–16 years with autism spectrum disorders (ASD) or nonspectrum diagnoses, a subset of 1807 assessments from 1118 individuals with ASD were divided into narrow age- and language-cells. Within each cell, severity scores were based on percentiles of raw totals corresponding to each ADOS diagnostic classification. Calibrated severity scores had more uniform distributions across developmental groups and were less influenced by participant demographics than raw totals. This metric should be useful in comparing assessments across modules and time, and identifying trajectories of autism severity for clinical, genetic, and neurobiological research.
DOI: 10.1002/ajmg.10188
发表时间: 2002-03-08
期刊: AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子: --
作者:
Spiker, D;Lotspeich, LJ;Risch, N
通讯作者: Risch, N
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发表时间: 2000-05-01
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DOI: 10.1007/s10803-006-0280-1
发表时间: 2007-04-01
影响因子: 3.9
作者:
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通讯作者: Lord, Catherine
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发表时间: 1988-03-01
影响因子: 3.9
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