Standardizing ADOS scores for a measure of severity in autism spectrum disorders.
Standardizing ADOS scores for a measure of severity in autism spectrum disorders.
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DOI:
10.1007/s10803-008-0674-3
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发表时间:
2009-05
影响因子:
3.9
通讯作者:
Lord, Catherine
中科院分区:
文献类型:
--
作者:
Gotham, Katherine;Pickles, Andrew;Lord, Catherine
The aim of this study is to standardize Autism Diagnostic Observation Schedule (ADOS) scores within a large sample to approximate an autism severity metric. Using a dataset of 1415 individuals aged 2–16 years with autism spectrum disorders (ASD) or nonspectrum diagnoses, a subset of 1807 assessments from 1118 individuals with ASD were divided into narrow age- and language-cells. Within each cell, severity scores were based on percentiles of raw totals corresponding to each ADOS diagnostic classification. Calibrated severity scores had more uniform distributions across developmental groups and were less influenced by participant demographics than raw totals. This metric should be useful in comparing assessments across modules and time, and identifying trajectories of autism severity for clinical, genetic, and neurobiological research.
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DOI:
10.1002/ajmg.10188
发表时间:
2002-03-08
期刊:
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子:
--
作者:
Spiker, D;Lotspeich, LJ;Risch, N
通讯作者:
Risch, N
影响因子:
7.6
作者:
Pickles, A;Starr, E;Rutter, M
通讯作者:
Rutter, M
影响因子:
3.9
作者:
Gotham, Katherine;Risi, Susan;Lord, Catherine
通讯作者:
Lord, Catherine
影响因子:
3.9
作者:
VOLKMAR, FR;CICCHETTI, DV;COHEN, DJ
通讯作者:
COHEN, DJ
影响因子:
3.9
作者:
Constantino, JN;Davis, SA;Reich, W
通讯作者:
Reich, W