Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man.
Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man.
复制标题
DOI：
10.1111/j.1742-1241.2010.02523.x
复制
发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Hemnes AR
中科院分区：
文献类型：
--
作者：
Pugh ME;Hemnes AR
Pulmonary arterial hypertension (PAH) is a complex disease with significant morbidity and mortality. Recent animal and human studies have highlighted abnormalities in regulation and metabolism of insulin, sex hormones, adipokines, and lipids that may play a role in disease development. Mouse studies suggest features of the metabolic syndrome including insulin resistance, deficiencies in PPARγ and apolipoprotein E, and low adiponectin are linked to development of PAH. In humans, insulin resistance, the metabolic syndrome, and low levels of high-density lipoprotein have been associated with PAH. In addition, abnormal metabolism of estrogens has been demonstrated in human and animal models of PAH, suggesting an important relationship of sex hormones and pulmonary vascular disease. Improved understanding of how metabolic and hormonal derangements relate to development and progression of pulmonary hypertension may lead to better disease therapies and understanding of potential risk factors. This review will focus on the animal and human data regarding metabolic and sex hormone derangements in PAH.
登录
查看更多内容
影响因子：
158.5
作者：
Du, Lingling;Sullivan, Christopher C.;Thistlethwaite, Patricia A.
通讯作者：
Thistlethwaite, Patricia A.
DOI：
10.1073/pnas.2536828100
发表时间：
2003-12-23
影响因子：
11.1
作者：
He, WM;Barak, Y;Evans, RM
通讯作者：
Evans, RM
影响因子：
15.9
作者：
Hansmann, Georg;de Jesus Perez, Vinicio A.;Rabinovitch, Marlene
通讯作者：
Rabinovitch, Marlene
DOI：
10.1183/09031936.00010409
发表时间：
2009-11
期刊：
The European respiratory journal
影响因子：
--
作者：
Austin ED;Cogan JD;West JD;Hedges LK;Hamid R;Dawson EP;Wheeler LA;Parl FF;Loyd JE;Phillips JA 3rd
通讯作者：
Phillips JA 3rd
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.