Tracing the legacy of the early Hainan Islanders--a perspective from mitochondrial DNA.
Tracing the legacy of the early Hainan Islanders--a perspective from mitochondrial DNA.
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DOI：
10.1186/1471-2148-11-46
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发表时间：
2011-02-15
影响因子：
3.4
通讯作者：
Zhang YP
中科院分区：
文献类型：
--
作者：
Peng MS;He JD;Liu HX;Zhang YP
海南岛位于东亚和东南亚交界处，在末次盛冰期与大陆相连。这为晚更新世现代人类在海南岛的定居提供了契机。古代的迁徙是否在当代海南岛人的基因库中留下了任何足迹是有争议的。我们收集了285个黎族个体的样本，并分析了线粒体DNA（mtDNA）高变序列I和II（HVS-I和II）的变异，以及部分编码区。结合前人的研究资料，重建了海南岛居民的生殖史。结果表明，海南岛居民与中国大陆南方人群，特别是广西人群的关系密切。单倍型共享分析表明，最近来自大陆的基因流可能在形成海南岛居民的母系库中发挥重要作用。更重要的是，单倍群M12、M7 e和M7 c1 * 可能代表了居住在这一地区的古代人群的遗传遗迹;因此，14个代表性的完整mtDNA基因组被进一步测序。单倍群M12、M7 e和M7 c1 * 的详细地理分布分析表明，现代人类在海南岛的早期定居可以追溯到全新世早期甚至晚更新世晚期，约7 - 27千年。这些结果与Y染色体和考古学研究相对应。
Hainan Island is located around the conjunction of East Asia and Southeast Asia, and during the Last Glacial Maximum (LGM) was connected with the mainland. This provided an opportunity for the colonization of Hainan Island by modern human in the Upper Pleistocene. Whether the ancient dispersal left any footprints in the contemporary gene pool of Hainan islanders is debatable. We collected samples from 285 Li individuals and analyzed mitochondrial DNA (mtDNA) variations of hypervariable sequence I and II (HVS-I and II), as well as partial coding regions. By incorporating previously reported data, the phylogeny of Hainan islanders was reconstructed. We found that Hainan islanders showed a close relationship with the populations in mainland southern China, especially from Guangxi. Haplotype sharing analyses suggested that the recent gene flow from the mainland might play important roles in shaping the maternal pool of Hainan islanders. More importantly, haplogroups M12, M7e, and M7c1* might represent the genetic relics of the ancient population that populated this region; thus, 14 representative complete mtDNA genomes were further sequenced. The detailed phylogeographic analyses of haplogroups M12, M7e, and M7c1* indicated that the early peopling of Hainan Island by modern human could be traced back to the early Holocene and/or even the late Upper Pleistocene, around 7 - 27 kya. These results correspond to both Y-chromosome and archaeological studies.
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