A Domain Constrained Deformable (DoCD) Model for Co-registration of Pre- and Post-Radiated Prostate MRI.
A Domain Constrained Deformable (DoCD) Model for Co-registration of Pre- and Post-Radiated Prostate MRI.
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域限制的变形（DOCD）模型，用于共同注册前后的前列腺MRI。
DOI：
10.1016/j.neucom.2014.01.058
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发表时间：
2014-11-20
期刊：
影响因子：
6
通讯作者：
Madabhushi, Anant
中科院分区：
文献类型：
--
作者：
Toth, Robert;Traughber, Bryan;Ellis, Rodney;Kurhanewicz, John;Madabhushi, Anant
外束放射治疗 (EBRT) 是治疗前列腺癌 (CaP) 的一种常用方法，涉及用电离辐射破坏肿瘤细胞。 EBRT 后，生化失败与疾病复发有关。然而，需要评估早期治疗相关变化的方法，以便在疾病反应不完全的情况下进行早期干预。查看治疗评估的一种方法是在治疗后逐个体素地检测 MRI 标记物的变化。 MRI 标记物的变化可能与疾病复发以及完全或部分缓解相关。为了促进与治疗变化相关的逐体素成像，并评估治疗后腺体的形态变化，必须首先通过图像配准将辐射前和辐射后 MRI 进行空间对准。然而，放射治疗后，EBRT 会引起前列腺体积的变化和前列腺内部解剖结构的扭曲。前列腺的内部亚结构、中央腺体 (CG) 和周围区 (PZ) 对辐射的反应可能不同，并且它们的形状可能会发生巨大变化。先前提出的前列腺生物力学模型倾向于关注外力如何影响前列腺表面（而不是内部），并假设前列腺是一个保持体积的实体。在这项工作中，我们提出了 DoCD，一种用于自动配准 EBRT 前、后 MRI 的生物力学模型，目的是明确建模 (1) 体积变化，以及 (2) CG 和 PZ 的变化。 DoCD 应用于 30 名患者的队列，获得了 2.994 毫米的均方根误差，这在统计学上显着优于未考虑前列腺内部解剖结构变化的传统生物力学模型（平均值为 5.071 毫米）。
External beam radiation treatment (EBRT) is a popular method for treating prostate cancer (CaP) involving destroying tumor cells with ionizing radiation. Following EBRT, biochemical failure has been linked with disease recurrence. However, there is a need for methods for evaluating early treatment related changes to allow for an early intervention in case of incomplete disease response. One method for looking at treatment evaluation is to detect changes in MRI markers on a voxel-by-voxel basis following treatment. Changes in MRI markers may be correlated with disease recurrence and complete or partial response. In order to facilitate voxel-by-voxel imaging related treatment changes, and also to evaluate morphologic changes in the gland post treatment, the pre- and post-radiated MRI must first be brought into spatial alignment via image registration. However, EBRT induces changes in the prostate volume and distortion to the internal anatomy of the prostate following radiation treatment. The internal substructures of the prostate, the central gland (CG) and peripheral zone (PZ), may respond to radiation differently, and their resulting shapes may change drastically. Biomechanical models of the prostate that have been previously proposed tend to focus on how external forces affect the surface of the prostate (not the internals), and assume that the prostate is a volume-preserving entity. In this work we present DoCD, a biomechanical model for automatically registering pre-, post-EBRT MRI with the aim of expressly modeling the (1) changes in volume, and (2) changes to the CG and PZ. DoCD was applied to a cohort of 30 patients and achieved a root mean square error of 2.994 mm, which was statistically significantly better a traditional biomechanical model which did not consider changes to the internal anatomy of the prostate (mean of 5.071 mm).
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