Naturally occurring canine sarcomas: Bridging the gap from mouse models to human patients through cross-disciplinary research partnerships.
Naturally occurring canine sarcomas: Bridging the gap from mouse models to human patients through cross-disciplinary research partnerships.
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DOI：
10.3389/fonc.2023.1130215
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发表时间：
2023
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
在美国国家癌症研究所“癌症登月计划”的支持下，过去几年，人们对犬自发性癌症模型重新产生了兴趣，将其作为转化肿瘤学研究的宝贵资源。越来越多的人意识到，患有癌症的宠物狗为提高癌症药物发现和临床治疗开发的效率提供了一个可行的桥梁。犬类肿瘤与人类肿瘤具有许多相同的生物学、遗传和组织学特征，最重要的是，它们保留了自然发生的耐药性、转移和肿瘤-宿主免疫相互作用的复杂性，所有这些都难以在诱导或基因工程小鼠肿瘤模型中概括。犬类模型的效用在肉瘤研究中尤为明显，犬类肉瘤的发病率比人高，这促进了比较研究，从而使两种动物的治疗进展都受益。尽管人们越来越意识到使用自发性犬肉瘤模型进行研究的优势，但这些模型仍未得到充分利用，部分原因是缺乏更永久的机构和跨机构基础设施来支持兽医和人类临床科学家之间的伙伴关系。在这篇综述中，我们提供了一个最新的历史和目前的应用，自发发生的犬肿瘤模型在肉瘤研究中，特别关注知识的差距，局限性和发展机会在这些应用。此外，我们建议考虑在现有的兽医转化和比较肿瘤学研究基础设施中工作，以最大限度地提高兽医和人类生物医学研究人员在机构内部和跨机构之间的合作伙伴关系，以提高自发性犬肉瘤在转化肿瘤学研究中的效用和应用。
Fueled by support from the National Cancer Institute’s “Cancer Moonshot” program, the past few years have witnessed a renewed interest in the canine spontaneous cancer model as an invaluable resource in translational oncology research. Increasingly, there is awareness that pet dogs with cancer provide an accessible bridge to improving the efficiency of cancer drug discovery and clinical therapeutic development. Canine tumors share many biological, genetic, and histologic features with their human tumor counterparts, and most importantly, retain the complexities of naturally occurring drug resistance, metastasis, and tumor-host immune interactions, all of which are difficult to recapitulate in induced or genetically engineered murine tumor models. The utility of canine models has been particularly apparent in sarcoma research, where the increased incidence of sarcomas in dogs as compared to people has facilitated comparative research resulting in treatment advances benefitting both species. Although there is an increasing awareness of the advantages in using spontaneous canine sarcoma models for research, these models remain underutilized, in part due to a lack of more permanent institutional and cross-institutional infrastructure to support partnerships between veterinary and human clinician-scientists. In this review, we provide an updated overview of historical and current applications of spontaneously occurring canine tumor models in sarcoma research, with particular attention to knowledge gaps, limitations, and growth opportunities within these applications. Furthermore, we propose considerations for working within existing veterinary translational and comparative oncology research infrastructures to maximize the benefit of partnerships between veterinary and human biomedical researchers within and across institutions to improve the utility and application of spontaneous canine sarcomas in translational oncology research.
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