Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report.

Long-term survival of a patient with scalp angiosarcoma and multiple metastases treated using combination therapy: A case report.
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头皮肉瘤患者的长期生存和使用联合疗法治疗的多个转移酶的长期存活:病例报告。

DOI:
10.3892/ol.2015.2919
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发表时间:
2015-04
期刊:
影响因子:
2.9
通讯作者:
Yuan Y
Yuan Y
中科院分区:
医学4区
文献类型:
--
作者:
Ye J;Li XF;Wang YD;Yuan Y

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血管肉瘤是一种罕见且致命的恶性肿瘤,起源于血管内皮细胞。手术是治愈这种疾病最有效的方法,但对于转移性血管肉瘤,以化疗为基础的治疗是主要的治疗选择。然而,目前尚无标准的化疗方案。目前的研究报道了一名 66 岁男性术后头皮血管肉瘤复发并多发转移的病例。该患者对由环磷酰胺、表柔比星、长春新碱和达卡巴嗪组成的一线联合化疗获得完全缓解,无进展生存期为八个月。经过后续的环磷酰胺、表柔比星、长春新碱、达卡巴嗪、多西紫杉醇、顺铂、吉西他滨以及放疗和抗血管生成治疗等综合治疗,患者初诊后获得了38个月的总生存期。
Angiosarcoma is a rare and deadly malignancy originating from the vascular endothelial cells. Surgery is the most effective method to cure this disease, but for metastatic angiosarcoma, a chemotherapy-based treatment is the main therapeutic choice. However, there is currently no standard chemotherapy regimen. The current study reports the case of a 66-year-old male with post-operative scalp angiosarcoma recurrence and multiple metastases. The patient obtained a complete response to first-line combination chemotherapy consisting of cyclophosphamide, epirubicin, vincristine and dacarbazine, with a progression-free survival time of eight months. After benefitting from subsequent comprehensive treatment including, cyclophosphamide, epirubicin, vincristine, dacarbazine, docetaxel, cisplatin, gemcitabine and radiotherapy and anti-angiogenic therapy, the patient obtained an overall survival time of 38 months following initial diagnosis.
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