Synthetic biological approaches to natural product biosynthesis.
Synthetic biological approaches to natural product biosynthesis.
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DOI：
10.1016/j.copbio.2011.12.016
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发表时间：
2012-10
影响因子：
7.7
通讯作者：
Tang, Yi
中科院分区：
文献类型：
--
作者：
Winter, Jaclyn M.;Tang, Yi
Small molecules produced in Nature continue to be an inspiration for the development of new therapeutic agents. These natural products possess exquisite chemical diversity, which gives rise to their wide range of biological activities. In their host organism, natural products are assembled and modified by dedicated biosynthetic pathways that Nature has meticulously developed. Often times, the complex structures or chemical modifications instated by these pathways are difficult to replicate using traditional synthetic methods. An alternative approach for creating or enhancing the structural variation of natural products is through combinatorial biosynthesis. By rationally reprogramming and manipulating the biosynthetic machinery responsible for their production, unnatural metabolites that were otherwise inaccessible can be obtained. Additionally, new chemical structures can be synthesized or derivatized by developing the enzymes that carry out these complicated chemical reactions into biocatalysts. In this review, we will discuss a variety of combinatorial biosynthetic strategies, their technical challenges, and highlight some recent (since 2007) examples of rationally designed unnatural metabolites, as well as platforms that have been established for the production and modification of clinically important pharmaceutical compounds.
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作者：
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通讯作者：
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DOI：
10.1126/science.1191652
发表时间：
2010-10-01
期刊：
Science (New York, N.Y.)
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DOI：
10.1073/pnas.0337542100
发表时间：
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影响因子：
11.1
作者：
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通讯作者：
Chater, KF