Peroxiredoxins as Potential Targets for Cardiovascular Disease.
Peroxiredoxins as Potential Targets for Cardiovascular Disease.
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DOI：
10.3390/antiox10081244
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发表时间：
2021-08-03
期刊：
影响因子：
--
通讯作者：
Oh GT
中科院分区：
文献类型：
--
作者：
Jeong SJ;Park JG;Oh GT
Increased oxidative stress (OS) is considered a common etiology in the pathogenesis of cardiovascular disease (CVD). Therefore, the precise regulation of reactive oxygen species (ROS) in cardiovascular cells is essential to maintain normal physiological functions. Numerous regulators of cellular homeostasis are reportedly influenced by ROS. Hydrogen peroxide (H2O2), as an endogenous ROS in aerobic cells, is a toxic substance that can induce OS. However, many studies conducted over the past two decades have provided substantial evidence that H2O2 acts as a diffusible intracellular signaling messenger. Antioxidant enzymes, including superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins (Prdxs), maintain the balance of ROS levels against augmentation of ROS production during the pathogenesis of CVD. Especially, Prdxs are regulatory sensors of transduced intracellular signals. The intracellular abundance of Prdxs that specifically react with H2O2 act as regulatory proteins. In this review, we focus on the role of Prdxs in the regulation of ROS-induced pathological changes in the development of CVD.
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DOI：
10.3390/antiox10030346
发表时间：
2021-02-25
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Sim J;Park J;Woo HA;Rhee SG
通讯作者：
Rhee SG
DOI：
10.3390/antiox10060925
发表时间：
2021-06-07
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
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通讯作者：
Chatterjee S
DOI：
10.1073/pnas.91.15.7017
发表时间：
1994-07-19
影响因子：
11.1
作者：
CHAE, HZ;ROBISON, K;RHEE, SG
通讯作者：
RHEE, SG
DOI：
10.1073/pnas.87.13.5134
发表时间：
1990-07-01
影响因子：
11.1
作者：
CUSHING, SD;BERLINER, JA;FOGELMAN, AM
通讯作者：
FOGELMAN, AM
影响因子：
37.8
作者：
Förstermann, U;Münzel, T
通讯作者：
Münzel, T