Inferiority complex: why do sensory ion channels multimerize?
Inferiority complex: why do sensory ion channels multimerize?
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DOI：
10.1042/bst20211002
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发表时间：
2022-02-28
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
外周躯体感觉神经配备了多功能的分子传感器，可以对物理环境的急剧变化做出反应。这些传感器中的大多数都是离子通道，当被激活时，它们会使感觉神经末梢去极化，导致它产生动作电位，这是产生包括疼痛在内的大多数躯体感觉的第一步。感觉离子通道的激活和失活受到多种机制的严格调控和调节。这些机制之一是通过与感觉神经末梢质膜上的多蛋白复合体中的其他蛋白质直接分子相互作用来调节感觉离子通道的活性。在这篇简短的综述中，我们将考虑围绕一个原型感觉受体--瞬时受体潜力香草素1型(TRPV1)形成的这种复合体的几个例子。我们还将讨论由众多已报道的复合体引起的一些固有的概念性困难。
Peripheral somatosensory nerves are equipped with versatile molecular sensors which respond to acute changes in the physical environment. Most of these sensors are ion channels that, when activated, depolarize the sensory nerve terminal causing it to generate action potentials, which is the first step in generation of most somatic sensations, including pain. The activation and inactivation of sensory ion channels is tightly regulated and modulated by a variety of mechanisms. Amongst such mechanisms is the regulation of sensory ion channel activity via direct molecular interactions with other proteins in multi-protein complexes at the plasma membrane of sensory nerve terminals. In this brief review, we will consider several examples of such complexes formed around a prototypic sensory receptor, transient receptor potential vanilloid type 1 (TRPV1). We will also discuss some inherent conceptual difficulties arising from the multitude of reported complexes.
DOI：
10.3390/ph5030249
发表时间：
2012-02-23
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Berg KA;Patwardhan AM;Akopian AN
通讯作者：
Akopian AN
影响因子：
4.8
作者：
Jeske NA
通讯作者：
Jeske NA