Macrophage Tropism in Pathogenic HIV-1 and SIV Infections.
Macrophage Tropism in Pathogenic HIV-1 and SIV Infections.
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DOI：
10.3390/v12101077
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发表时间：
2020-09-25
期刊：
影响因子：
--
通讯作者：
Joseph SB
中科院分区：
文献类型：
--
作者：
Moeser M;Nielsen JR;Joseph SB
Most myeloid lineage cells express the receptor and coreceptors that make them susceptible to infection by primate lentiviruses (SIVs and HIVs). However, macrophages are the only myeloid lineage cell commonly infected by SIVs and/or HIVs. The frequency of infected macrophages varies greatly across specific host and virus combinations as well as disease states, with infection rates being greatest in pathogenic SIV infections of non-natural hosts (i.e., Asian nonhuman primates (Asian NHPs)) and late in untreated HIV-1 infection. In contrast, macrophages from natural SIV hosts (i.e., African NHPs) are largely resistant to infection due to entry and/or post-entry restriction mechanisms. These highly variable rates of macrophage infection may stem from differences in the host immune environment, entry and post-entry restriction mechanisms, the ability of a virus to adapt to efficiently infect macrophages, and the pleiotropic effects of macrophage-tropism including the ability to infect cells lacking CD4 and increased neutralization sensitivity. Questions remain about the relationship between rates of macrophage infection and viral pathogenesis, with some evidence suggesting that elevated levels of macrophage infection may contribute to greater pathogenesis in non-natural SIV hosts. Alternatively, extensive infection of macrophages may only emerge in the context of high viral loads and immunodeficiency, making it a symptom of highly pathogenic infections, not a primary driver of pathogenesis.
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影响因子：
3.2
作者：
Beck SE;Queen SE;Metcalf Pate KA;Mangus LM;Abreu CM;Gama L;Witwer KW;Adams RJ;Zink MC;Clements JE;Mankowski JL
通讯作者：
Mankowski JL
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
3.3
作者：
Francella N;Elliott ST;Yi Y;Gwyn SE;Ortiz AM;Li B;Silvestri G;Paiardini M;Derdeyn CA;Collman RG
通讯作者：
Collman RG
影响因子：
6.4
作者：
Avalos CR;Abreu CM;Queen SE;Li M;Price S;Shirk EN;Engle EL;Forsyth E;Bullock BT;Mac Gabhann F;Wietgrefe SW;Haase AT;Zink MC;Mankowski JL;Clements JE;Gama L
通讯作者：
Gama L
影响因子：
11.2
作者：
Churchill, Melissa J.;Wesselingh, Steven L.;Gorry, Paul R.
通讯作者：
Gorry, Paul R.