O-GlcNAc: a novel regulator of immunometabolism.
O-GlcNAc: a novel regulator of immunometabolism.
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DOI：
10.1007/s10863-018-9744-1
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发表时间：
2018-06
影响因子：
3
通讯作者：
Fields PE
中科院分区：
文献类型：
--
作者：
Machacek M;Slawson C;Fields PE
免疫代谢的快速扩展领域集中在代谢如何控制免疫细胞的功能。CD 4 + T细胞对于导致特定病原体根除的适应性免疫应答是必需的。然而，当T细胞过度活跃时，它们可以驱动自身免疫，过敏性疾病和慢性炎症。代谢变化影响CD 4 + T细胞功能的机制尚不完全清楚。翻译后蛋白质修饰，O-GlcNAc（O-连接的β-N-乙酰葡糖胺），随着细胞对环境的响应和代谢途径的变化，动态地循环细胞内蛋白质的开启和关闭。随着O-GlcNAc循环速率的波动，蛋白质功能、稳定性和/或定位可能受到影响。因此，O-GlcNAc在细胞代谢和功能的关系中处于关键地位。本文综述了影响CD 4 + T细胞活化和分化的细胞内和细胞外代谢因素以及O-GlcNAc如何调节这些过程。我们还提出了未来研究的领域，这些领域可能会阐明O-GlcNAc在CD 4 + T细胞的可塑性和致病性中的作用，并发现新的潜在治疗靶点。
The rapidly expanding field of immunometabolism focuses on how metabolism controls the function of immune cells. CD4+ T cells are essential for the adaptive immune response leading to the eradication of specific pathogens. However, when T cells are inappropriately over-active, they can drive autoimmunity, allergic disease, and chronic inflammation. The mechanisms by which metabolic changes influence function in CD4+ T cells are not fully understood. The post-translational protein modification, O-GlcNAc (O-linked β-N-acetylglucosamine), dynamically cycles on and off of intracellular proteins as cells respond to their environment and flux through metabolic pathways changes. As the rate of O-GlcNAc cycling fluctuates, protein function, stability, and/or localization can be affected. Thus, O-GlcNAc is critically poised at the nexus of cellular metabolism and function. This review highlights the intra- and extracellular metabolic factors that influence CD4+ T cell activation and differentiation and how O-GlcNAc regulates these processes. We also propose areas of future research that may illuminate O-GlcNAc’s role in the plasticity and pathogenicity of CD4+ T cells and uncover new potential therapeutic targets.
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影响因子：
4.8
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