Is e-cigarette use in non-smoking young adults associated with later smoking? A systematic review and meta-analysis.
Is e-cigarette use in non-smoking young adults associated with later smoking? A systematic review and meta-analysis.
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DOI：
10.1136/tobaccocontrol-2019-055433
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发表时间：
2020-03-10
期刊：
影响因子：
5.2
通讯作者：
Munafò MR
中科院分区：
文献类型：
--
作者：
Khouja JN;Suddell SF;Peters SE;Taylor AE;Munafò MR
本综述的目的是调查年轻非吸烟者使用电子烟与不使用电子烟是否与随后吸烟有关。 PubMed、Embase、Web of Science、Wiley Cochrane 图书馆数据库以及 2018 年尼古丁和烟草研究学会和行为医学学会会议摘要。所有针对年轻人（30 岁以下）的研究均包含在吸烟前测量电子烟使用情况以及可计算 OR 的吸烟结果测量（不包括评论和动物研究）。独立提取由多位作者使用预先准备的提取表格完成。在 9199 项结果中，荟萃分析纳入了 17 项研究。当在随机效应模型中对结果进行荟萃分析时，有强有力的证据表明非吸烟者使用电子烟与后来吸烟之间存在关联（OR：4.59，95％CI：3.60至5.85）。然而，异质性很高（I2=88%）。尽管非吸烟者使用电子烟与随后吸烟之间的关联似乎很强，但现有证据由于依赖于未经生化验证的吸烟史自我报告措施而受到限制。没有一项研究包含阴性对照，这将为证明这种关联是否可能存在因果关系提供更有力的证据。许多证据也未能考虑非吸烟者使用的电子液体中的尼古丁含量，这意味着很难就尼古丁是否是驱动这种关联的机制做出结论。
The aim of this review was to investigate whether e-cigarette use compared with non-use in young non-smokers is associated with subsequent cigarette smoking. PubMed, Embase, Web of Science, Wiley Cochrane Library databases, and the 2018 Society for Research on Nicotine and Tobacco and Society for Behavioural Medicine conference abstracts. All studies of young people (up to age 30 years) with a measure of e-cigarette use prior to smoking and an outcome measure of smoking where an OR could be calculated were included (excluding reviews and animal studies). Independent extraction was completed by multiple authors using a preprepared extraction form. Of 9199 results, 17 studies were included in the meta-analysis. There was strong evidence for an association between e-cigarette use among non-smokers and later smoking (OR: 4.59, 95% CI: 3.60 to 5.85) when the results were meta-analysed in a random-effects model. However, there was high heterogeneity (I2=88%). Although the association between e-cigarette use among non-smokers and subsequent smoking appears strong, the available evidence is limited by the reliance on self-report measures of smoking history without biochemical verification. None of the studies included negative controls which would provide stronger evidence for whether the association may be causal. Much of the evidence also failed to consider the nicotine content of e-liquids used by non-smokers meaning it is difficult to make conclusions about whether nicotine is the mechanism driving this association.
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DOI：
10.1001/jama.2015.8950
发表时间：
2015-08-18
期刊：
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影响因子：
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影响因子：
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