Diverse effect of tributyltin on apoptosis in PC12 cells.
Diverse effect of tributyltin on apoptosis in PC12 cells.
复制标题
三丁基锡对 PC12 细胞凋亡的多种影响。
DOI：
10.1006/bbrc.2000.2810
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发表时间：
2000
影响因子：
3.1
通讯作者：
Toshio Iwakuma
中科院分区：
文献类型：
--
作者：
Osamu Yamanoshita;M. Kurasaki;T. Saito;Kyoko Takahasi;Hiroko Sasaki;T. Hosokawa;Masashi Okabe;Jyunko Mochida;Toshio Iwakuma
目前还没有完全阐明内分泌干扰物是如何扰乱激素功能的，或者它们的影响与自然荷尔蒙相比有多大。关于三丁基锡(TBT)对生物的影响的信息很少，三丁基锡是一种内分泌干扰物。高浓度TBT诱导PC12细胞凋亡，低浓度TBT抑制无血清或含6-羟基多巴胺培养的PC12细胞DNA片段化。经TBT处理后，在两种培养条件下生长的细胞存活率均有所提高。提示TBT具有诱导和抑制细胞凋亡的作用。TBT对细胞凋亡的不同影响可能会对细胞分化造成严重的损害。
It has not been fully elucidated how endocrine-disrupting chemicals disrupt hormone functions or how strong their effects are compared with natural hormones. There is little information concerning the effects of tributyltin (TBT), one of the endocrine disrupters on living organisms. Although TBT at high concentration induced apoptosis in PC12 cells, TBT at low concentration inhibited the DNA fragmentation in the cells cultured in serum-free medium or in medium containing 6-hydroxydopamine. The cell viability grown in both medium conditions increased after treatment with TBT. These findings suggest that TBT exerted a apoptosis-inducing and -inhibiting effect. These diverse effect of TBT on apoptosis would cause serious damages on cell differentiation.
影响因子：
4.8
作者：
Heimler, I;Rawlins, RG;Hutz, RJ
通讯作者：
Hutz, RJ
影响因子：
10.4
作者：
Soto AM;Justicia H;Wray JW;Sonnenschein C
通讯作者：
Sonnenschein C