Nanovehicular intracellular delivery systems.
Nanovehicular intracellular delivery systems.
复制标题
纳米细胞内输送系统。
DOI：
10.1002/jps.21270
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发表时间：
2008-09
影响因子：
3.8
通讯作者：
Davidson, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Prokop, Ales;Davidson, Jeffrey M.
关键词：
本文综述了纳米载体（NV）介导的药物和基因在细胞内转运、蓄积和滞留（统称为药物递送）的原理和障碍。目的是将货物递送到特定的细胞内位点，如果可能的话，以发挥局部作用。本文中讨论的一些原则适用于不能透过质膜或血脑屏障的非胶体药物。NV被定义为导致能够进入细胞和组织并在细胞内递送货物的胶体物体的各种纳米尺寸的颗粒。讨论了不同的定位和瞄准手段。还对药代动力学和药效学进行了有限的讨论。NVs与微递送和已经在商业使用中的当前纳米技术形成对比。概述了NV技术的新发展，并强调了未来的应用。我们还简要回顾了现有的建模工具和方法，以定量描述血管和肿瘤隔室内的靶向NV的行为，这是一个特别重要的领域。虽然我们列出了“基本”的现象与不同程度的复杂性交付给癌症，我们也强调多尺度建模和自下而上的系统生物学方法的重要性。
This article provides an overview of principles and barriers relevant to intracellular drug and gene transport, accumulation and retention (collectively called as drug delivery) by means of nanovehicles (NV). The aim is to deliver a cargo to a particular intracellular site, if possible, to exert a local action. Some of the principles discussed in this article apply to noncolloidal drugs that are not permeable to the plasma membrane or to the blood–brain barrier. NV are defined as a wide range of nanosized particles leading to colloidal objects which are capable of entering cells and tissues and delivering a cargo intracelullarly. Different localization and targeting means are discussed. Limited discussion on pharmacokinetics and pharmacodynamics is also presented. NVs are contrasted to micro-delivery and current nanotechnologies which are already in commercial use. Newer developments in NV technologies are outlined and future applications are stressed. We also briefly review the existing modeling tools and approaches to quantitatively describe the behavior of targeted NV within the vascular and tumor compartments, an area of particular importance. While we list “elementary” phenomena related to different level of complexity of delivery to cancer, we also stress importance of multi-scale modeling and bottom-up systems biology approach.
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影响因子：
25.7
作者：
Adrian, JE;Poelstra, K;Kamps, JAAM
通讯作者：
Kamps, JAAM
影响因子：
8
作者：
Ala-aho, R;Ahonen, M;Kähäri, VM
通讯作者：
Kähäri, VM
DOI：
10.1073/pnas.152463399
发表时间：
2002-10-01
影响因子：
11.1
作者：
Åkerman, ME;Chan, WCW;Ruoslahti, E
通讯作者：
Ruoslahti, E
影响因子：
1.6
作者：
Araujo, RP;Petricoin, EF;Liotta, LA
通讯作者：
Liotta, LA
影响因子：
5.8
作者：
Awasthi, VD;Garcia, D;Phillips, WT
通讯作者：
Phillips, WT