Chemokine profile in women with moderate to severe anxiety and depression during pregnancy.
Chemokine profile in women with moderate to severe anxiety and depression during pregnancy.
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妊娠期中重度焦虑和抑郁妇女的趋化因子谱
DOI：
10.1186/s12884-021-04225-2
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发表时间：
2021-12-04
影响因子：
3.1
通讯作者：
Gelman PL
中科院分区：
文献类型：
--
作者：
Camacho-Arroyo I;Flores-Ramos M;Mancilla-Herrera I;Cruz FMC;Hernández-Ruiz J;Diaz GP;Labonne BF;Del Pilar Meza-Rodríguez M;Gelman PL
在正常和病理条件下，包括情绪相关障碍在内的受试者中，细胞因子水平已被广泛描述。关于趋化因子，很少有研究报道它们与妊娠期精神障碍的关系。因此，在本研究中，我们探索了妊娠晚期焦虑和抑郁妇女的趋化因子谱。采用汉密尔顿焦虑量表和汉密尔顿抑郁量表对126例妊娠晚期单独出现中重度焦虑(ANX)和中重度焦虑伴发抑郁(ANX + )的孕妇和40例正常对照孕妇进行测评。免疫分析法检测血清趋化因子：单核细胞趋化蛋白-1(CCL2)、RANTES(CCL5)、IP-10(CXCL10)、嗜酸性粒细胞趋化因子(CCL11)、嗜酸性粒细胞趋化因子受体(TACL17)、MIP-1α(CCL3)、MIP-1β(CCL4)、MIG(CXCL9)、MIP-3α(CCL20)、ENA-78(CXCL5)、Groα(CXCL1)、I-TAC(CXCL11)和IL-8(CXCL8)。临床、生化和社会人口学参数与HARS和HDRS评分值相关。与 + 组相比，ANX组和ANX CTRL DEP组的大多数趋化因子水平显著升高。MIP-1α/CCL3、MIP-1β/CCL4、MCP-1/CCL2、MIP-3α/CCL20、RANTES/CCL5、Eoaxin/CCL11和I-TAC/CXCL11与焦虑(HARS)和抑郁( )呈正相关(P<0.004)。焦虑(HARS)和抑郁(HDRS)得分较高(P<0.05)。在控制了AGE、 + 、GWK和 + 体重指数的临床指标后，发现趋化因子如IL-8/CXCL_8、MCP-1/CCL_2和MIP-1β/CCl_4在ANX组中与焦虑评分高相关(p<0.05； <0.05)。在ANX 组中，TARC/CCL17和嗜酸性粒细胞趋化因子/CCL11与抑郁的高分显著相关(P<0.05)，而MCP-1/CCL2和MIP-1α/CCL3与焦虑的高分显著相关(P<； 0.05)。多变量线性模型显示，在有症状组中，高水平的MIP-1β/CCL4和Eoaxin/CCL11仍与抑郁相关(P<0.05)，而IL-8/CXCL8、MIP-1 /CCL4、MCP-1/CCL2和MIP-1β/CCL3与焦虑相关(P<0.05)。我们的数据显示，在妊娠晚期表现出高水平情感症状的妇女，血清中不同的趋化因子水平会增加。我们的结果表明，焦虑、抑郁症状和情绪相关障碍水平的增加可能会促进与慢性炎症过程相关的特定功能趋化因子的变化。如果不加以控制，它可能会导致不良的产科和消极的新生儿结局、儿童发育和出生后生活中的神经精神变化。妊娠期情感性精神障碍患者的趋化因子水平升高。
Cytokine levels have been extensively described in pregnant subjects under normal and pathological conditions, including mood-related disorders. Concerning chemokines, very few studies have reported their association with psychiatric disorders during pregnancy. Therefore, we explored the chemokine profile in women exhibiting anxiety and depression during late pregnancy in the present study. One hundred twenty-six pregnant women in the 3rd trimester of pregnancy, displaying moderate to severe anxiety (ANX) alone and women exhibiting moderate to severe anxiety with comorbid depression (ANX + DEP), and 40 control pregnant women without affective disorders (CTRL) were evaluated through the Hamilton Anxiety Rating Scale (HARS) and the Hamilton Depression Rating Scale (HDRS). Serum chemokine levels of MCP-1 (CCL2), RANTES (CCL5), IP-10 (CXCL10), Eotaxin (CCL11), TARC (CCL17), MIP-1α (CCL3), MIP-1β (CCL4), MIG (CXCL9), MIP-3α (CCL20), ENA-78 (CXCL5), GROα (CXCL1), I-TAC (CXCL11) and IL-8 (CXCL8)] were measured by immunoassay. Clinical, biochemical, and sociodemographic parameters were correlated with HARS and HDRS score values. Serum levels of most chemokines were significantly higher in the ANX and in the ANX + DEP groups, when compared to the CTRL group. Positive correlations were observed between MIP-1α/CCL3, MIP-1β/CCL4, MCP-1/CCL2, MIP-3α/CCL20, RANTES/CCL5, Eotaxin/CCL11, and I-TAC/CXCL11 with high scores for anxiety (HARS) (p < 0.05) and for depression (HDRS) (p < 0.004). After controlling clinical measures for age + gwk + BMI, chemokines such as IL-8/CXCL8, MCP-1/CCL2 and MIP-1β/CCL4 were found associated with high scores for anxiety (p < 0.05) in the ANX group. TARC/CCL17 and Eotaxin/CCL11 showed significant associations with high scores for depression (p < 0.04) whereas, MCP-1/CCL2 and MIP-1α/CCL3 were significantly associated with high scores for anxiety (p < 0.05) in the ANX + DEP group. Using a multivariate linear model, high serum levels of MIP-1β/CCL4 and Eotaxin/CCL11 remained associated with depression (p < 0.01), while, IL-8/CXCL8, MIP-1β/CCL4, MCP-1/CCL2, and MIP-1α/CCL3 were associated with anxiety (p < 0.05) in the symptomatic groups. Our data show that serum levels of distinct chemokines are increased in women exhibiting high levels of affective symptoms during late pregnancy. Our results suggest that increased levels of anxiety, depressive symptoms, and mood-related disorders may promote changes in specific functional chemokines associated with a chronic inflammatory process. If not controlled, it may lead to adverse obstetric and negative neonate outcomes, child development and neuropsychiatric alterations in the postnatal life. Chemokine levels increase in affective disorders during pregnancy.
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影响因子：
3.4
作者：
Harper, Kathryn M.;Knapp, Darin J.;Park, Meredith A.;Breese, George R.
通讯作者：
Breese, George R.
影响因子：
6.8
作者：
Chen, Helen J.;Antonson, Adrienne M.;Gur, Tamar L.
通讯作者：
Gur, Tamar L.
影响因子：
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作者：
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通讯作者：
Schetter, Christine Dunkel
影响因子：
3.7
作者：
Domenici E;Willé DR;Tozzi F;Prokopenko I;Miller S;McKeown A;Brittain C;Rujescu D;Giegling I;Turck CW;Holsboer F;Bullmore ET;Middleton L;Merlo-Pich E;Alexander RC;Muglia P
通讯作者：
Muglia P
影响因子：
7.4
作者：
Britton, John R.
通讯作者：
Britton, John R.