Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
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DOI：
10.4049/jimmunol.1101812
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发表时间：
2011-12-15
期刊：
影响因子：
--
通讯作者：
Larmonier N
中科院分区：
文献类型：
--
作者：
LaCasse CJ;Janikashvili N;Larmonier CB;Alizadeh D;Hanke N;Kartchner J;Situ E;Centuori S;Har-Noy M;Bonnotte B;Katsanis E;Larmonier N
Dendritic cells (DCs) encompass a heterogeneous population of cells capable of orchestrating innate and adaptive immune responses. The ability of DCs to act as professional antigen presenting cells has been the foundation for the development and utilization of these cells as vaccines in cancer immunotherapy. DCs are also endowed with the non-conventional property of directly killing tumor cells. The current study investigates the regulation of murine DC cytotoxic function by T lymphocytes. We provide evidence that CD4+ Th-1, but not Th-2, Th-17 cells or Treg are capable of inducing DC cytotoxic function. IFN-γ was identified as the major factor responsible for Th-1-induced DC tumoricidal activity. Tumor cell killing mediated by Th-1-activated killer DCs (Th-1 KDCs) was dependent on inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production. Importantly, Th-1 KDCs were capable of presenting the acquired antigens from the killed tumor cells to T lymphocytes in vitro or in vivo. These observations open new possibilities for the application of KDCs in cancer immunotherapy.
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大鼠脾树突状细胞表达天然杀伤细胞受体蛋白1（NKR-P1），具有细胞毒性活性，可以通过CA2+依赖性机制选择靶标。
DOI：
10.1084/jem.186.3.467
发表时间：
1997-08-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Josien R;Heslan M;Soulillou JP;Cuturi MC
通讯作者：
Cuturi MC
影响因子：
7.8
作者：
Ma DY;Clark EA
通讯作者：
Clark EA
影响因子：
4.4
作者：
Chaperot, L;Blum, A;Plumas, J
通讯作者：
Plumas, J
影响因子：
4.4
作者：
Liu, SX;Yu, YZ;Cao, XT
通讯作者：
Cao, XT
影响因子：
11.2
作者：
Huang, J;Tatsumi, T;Storkus, WJ
通讯作者：
Storkus, WJ