Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism.
Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism.
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大鼠脾树突状细胞表达天然杀伤细胞受体蛋白1(NKR-P1),具有细胞毒性活性,可以通过CA2+依赖性机制选择靶标。
DOI:
10.1084/jem.186.3.467
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发表时间:
1997-08-04
期刊:
影响因子:
--
通讯作者:
Cuturi MC
中科院分区:
文献类型:
--
作者:
Josien R;Heslan M;Soulillou JP;Cuturi MC
Dendritic cells (DC) are a subset of leukocytes whose major function is antigen presentation. We investigated the phenotype and function of enriched (95–98.5%) rat DC. We show that both spleen and thymus DC express the natural killer cell receptor protein 1 (NKR-P1) as a disulfide linked homodimer of 60 kD. Freshly isolated DC express a low level of NKR-P1, which is strongly upregulated after overnight culture. Spleen, but not thymus DC, were able to kill the NK-sensitive YAC-1 cell line in vitro, and since this killing was Ca2+ dependent, a Fas ligand–Fas interaction was probably not involved. Besides their potent antigen-presenting function, DC can thus be cytotoxic for some tumor targets.
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影响因子:
15.3
作者:
Maraskovsky, E;Brasel, K;Teepe, M;Roux, ER;Lyman, SD;Shortman, K;McKenna, HJ
通讯作者:
McKenna, HJ
影响因子:
64.8
作者:
ARDAVIN, C;WU, L;SHORTMAN, K
通讯作者:
SHORTMAN, K
DOI:
10.1084/jem.177.1.195
发表时间:
1993-01-01
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
Rouvier E;Luciani MF;Golstein P
通讯作者:
Golstein P
DOI:
10.1084/jem.182.2.389
发表时间:
1995-08-01
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
Sallusto F;Cella M;Danieli C;Lanzavecchia A
通讯作者:
Lanzavecchia A
DOI:
10.1084/jem.185.5.941
发表时间:
1997-03-03
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
Dubois B;Vanbervliet B;Fayette J;Massacrier C;Van Kooten C;Brière F;Banchereau J;Caux C
通讯作者:
Caux C