Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism.

Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism.
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大鼠脾树突状细胞表达天然杀伤细胞受体蛋白1(NKR-P1),具有细胞毒性活性,可以通过CA2+依赖性机制选择靶标。

DOI:
10.1084/jem.186.3.467
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发表时间:
1997-08-04
期刊:
The Journal of experimental medicine
影响因子:
--
通讯作者:
Cuturi MC
Cuturi MC
中科院分区:
其他
文献类型:
--
作者:
Josien R;Heslan M;Soulillou JP;Cuturi MC

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Dendritic cells (DC) are a subset of leukocytes whose major function is antigen presentation. We investigated the phenotype and function of enriched (95–98.5%) rat DC. We show that both spleen and thymus DC express the natural killer cell receptor protein 1 (NKR-P1) as a disulfide linked homodimer of 60 kD. Freshly isolated DC express a low level of NKR-P1, which is strongly upregulated after overnight culture. Spleen, but not thymus DC, were able to kill the NK-sensitive YAC-1 cell line in vitro, and since this killing was Ca2+ dependent, a Fas ligand–Fas interaction was probably not involved. Besides their potent antigen-presenting function, DC can thus be cytotoxic for some tumor targets.
FLT3配体处理的小鼠功能成熟的树突状细胞数量的急剧增加:确定的多个树突状细胞亚群。
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