Quantitative phase imaging with epi-mode illumination for fiber-optic endoscopy

Quantitative phase imaging with epi-mode illumination for fiber-optic endoscopy
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用于光纤内窥镜的外延模式照明定量相位成像

DOI:
10.1117/12.2546402
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发表时间:
2020
期刊:
Quantitative Phase Imaging VI
影响因子:
--
通讯作者:
Robles, Francisco E.
Robles, Francisco E.
中科院分区:
--
文献类型:
--
作者:
Guang, Zhe;Ledwig, Patrick B.;Casteleiro Costa, Paloma;Robles, Francisco E.

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定量相位成像(QPI)提供了对细胞和亚细胞结构的独特访问,具有纳米级的灵敏度,使其成为生物样品非破坏性、无标记成像的宝贵工具。然而,QPI的实现通常涉及基于透射的几何形状,并且需要薄的样本,这阻止了QPI在许多重要的临床环境(包括内窥镜检查)中的使用。在这项工作中,我们展示了一个光纤设备,epi照明,能够提供定量的相位信息,非常适合临床内窥镜检查,以及其他生物医学应用。
Quantitative phase imaging (QPI) provides unique access to cellular and subcellular structures with nanometer-scale sensitivity, making it a valuable tool for non-destructive, label-free imaging of biological samples. However, implementation of QPI typically involves a transmission-based geometry and requires thin samples, preventing use of QPI in many important clinical settings, including endoscopy. In this work we demonstrate a fiber-optic device, with epi-illumination, capable of providing quantitative phase information that is well suited for clinical endoscopy, among other biomedical applications.
DOI: 10.1038/s41598-020-58474-w
发表时间: 2020-01-31
期刊: SCIENTIFIC REPORTS
影响因子: 4.6
作者:
Vicar, Tomas;Raudenska, Martina;Balvan, Jan
通讯作者: Balvan, Jan
DOI: 10.1364/boe.9.002743
发表时间: 2018-06-01
影响因子: 3.4
作者:
Ledwig, Patrick;Sghayyer, Moses;Robles, Francisco E.
通讯作者: Robles, Francisco E.
DOI: 10.1111/trf.15704
发表时间: 2020-02-14
期刊: TRANSFUSION
影响因子: 2.9
作者:
Costa, Paloma Casteleiro;Ledwig, Patrick;Robles, Francisco E.
通讯作者: Robles, Francisco E.