Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles.
Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles.
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从印刷纳米颗粒中掺入和受控释放甲硅烷基醚前药。
DOI：
10.1021/ja301710z
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发表时间：
2012-05-09
影响因子：
15
通讯作者：
Desimone, Joseph M.
中科院分区：
文献类型：
--
作者：
Parrott, Matthew C.;Finniss, Mathew;Luft, J. Chris;Pandya, Ashish;Gullapalli, Anuradha;Napier, Mary E.;Desimone, Joseph M.
合成了不对称双功能硅醚（ABS）化疗前药，并将其掺入到200 nm × 200 nm的颗粒中。选择吉西他滨的ABS前药作为模型化合物，是因为水溶性药物难以包封在水凝胶内。所得到的药物传递系统在酸性条件下被降解，并且发现只释放母体或活性药物。此外，改变硅原子上烷基取代基的空间体积可以调节药物释放速度，从而调节负载吉西他滨颗粒的细胞内毒性。这产生了一系列新型纳米颗粒，可以在数小时、数天或数月的时间内释放药物。
Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm x 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water soluble drug within a hydrogel. The resulting drug delivery systems were degraded under acidic conditions and were found to release only the parent or active drug. Furthermore, changing the steric bulk of the alkyl substituents on the silicon atom could regulate the rate of drug release and therefore the intracellular toxicity of the gemcitabine-loaded particles. This yielded a family of novel nanoparticles that could be tuned to release drug over the course of hours, days, or months.
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DOI：
10.1016/0006-291x(81)91644-2
发表时间：
1981-01-01
影响因子：
3.1
作者：
SHEN, WC;RYSER, HJP
通讯作者：
RYSER, HJP
影响因子：
4.5
作者：
Toncheva, V;Schacht, E;Heller, J
通讯作者：
Heller, J
DOI：
10.1016/j.jconrel.2011.01.009
发表时间：
2011-05-30
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Lin LY;Lee NS;Zhu J;Nyström AM;Pochan DJ;Dorshow RB;Wooley KL
通讯作者：
Wooley KL
影响因子：
10.8
作者：
Nunes J;Herlihy KP;Mair L;Superfine R;DeSimone JM
通讯作者：
DeSimone JM
影响因子：
15
作者：
Parrott, Matthew C.;Luft, J. Chris;Byrne, James D.;Fain, John H.;Napier, Mary E.;DeSimone, Joseph
通讯作者：
DeSimone, Joseph