The Diagnostic Accuracy of Second Trimester Plasma Glycated CD59 (pGCD59) to Identify Women with Gestational Diabetes Mellitus Based on the 75 g OGTT Using the WHO Criteria: A Prospective Study of Non-Diabetic Pregnant Women in Ireland.
The Diagnostic Accuracy of Second Trimester Plasma Glycated CD59 (pGCD59) to Identify Women with Gestational Diabetes Mellitus Based on the 75 g OGTT Using the WHO Criteria: A Prospective Study of Non-Diabetic Pregnant Women in Ireland.
复制标题
DOI：
10.3390/jcm11133895
复制
发表时间：
2022-07-04
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是评价妊娠中期血浆糖化CD59（pGCD59）（一种新型生物标志物）预测妊娠24 - 28周时2 h 75 g口服葡萄糖耐量试验结果的能力，采用2013年世界卫生组织标准。这是一项对378名孕妇的前瞻性研究。pGCD 59预测妊娠期糖尿病（GDM）的能力通过校正母体年龄、BMI、母体种族、产次、既往GDM和糖尿病家族史的ROC曲线进行评估。与正常葡萄糖耐量的女性相比，GDM女性的pGCD 59水平显著更高（p = 0.003）。pGCD59产生的用于鉴定GDM病例的校正AUC为0.65（95%CI：0.58 - 0.71，p <0.001）。pGCD 59预测GDM状态，其通过空腹血糖值5.1 mmol/L诊断，校正AUC为0.74（95%CI：0.65 - 0.81，p <0.001）。BMI亚组分析确定pGCD59在35 kg/m2 ≤ BMI <40 kg/m2（AUC：0.84 95%CI：0.69 - 0.98）和BMI ≥ 40 kg/m2（AUC：0.96 95%CI：0.86 - 0.99）类别中产生最高AUC。这项研究发现，妊娠中期pGCD 59是一个公平的预测GDM状态诊断的空腹血糖升高独立于BMI和一个很好的预测GDM在一个非常高的BMI的受试者。
The aim of this study was to evaluate the ability of second trimester plasma glycated CD59 (pGCD59), a novel biomarker, to predict the results of the 2 h 75 g oral glucose tolerance test at 24–28 weeks of gestation, employing the 2013 World Health Organisation criteria. This was a prospective study of 378 pregnant women. The ability of pGCD59 to predict gestational diabetes (GDM) was assessed using adjusted ROC curves for maternal age, BMI, maternal ethnicity, parity, previous GDM, and family history of diabetes. The pGCD59 levels were significantly higher in women with GDM compared to women with normal glucose tolerance (p = 0.003). The pGCD59 generated an adjusted AUC for identifying GDM cases of 0.65 (95%CI: 0.58–0.71, p < 0.001). The pGCD59 predicted GDM status diagnosed by a fasting glucose value of 5.1 mmol/L with an adjusted AUC of 0.74 (95%CI: 0.65–0.81, p < 0.001). Analysis of BMI subgroups determined that pGCD59 generated the highest AUC in the 35 kg/m2 ≤ BMI < 40 kg/m2 (AUC: 0.84 95%CI: 0.69–0.98) and BMI ≥ 40 kg/m2 (AUC: 0.96 95%CI: 0.86–0.99) categories. This study found that second trimester pGCD59 is a fair predictor of GDM status diagnosed by elevated fasting glucose independent of BMI and an excellent predictor of GDM in subjects with a very high BMI.
登录
查看更多内容
影响因子：
3.9
作者：
Bogdanet D;O'Shea P;Lyons C;Shafat A;Dunne F
通讯作者：
Dunne F
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
2.8
作者：
Benhalima K;Hanssens M;Devlieger R;Verhaeghe J;Mathieu C
通讯作者：
Mathieu C
影响因子：
8.2
作者：
Accardo-Palumbo, A;Triolo, G;Triolo, G
通讯作者：
Triolo, G
影响因子：
2.6
作者：
Hiersch, Liran;Berger, Howard;Melamed, Nir
通讯作者：
Melamed, Nir