The Oral Glucose Tolerance Test-Is It Time for a Change?-A Literature Review with an Emphasis on Pregnancy.

The Oral Glucose Tolerance Test-Is It Time for a Change?-A Literature Review with an Emphasis on Pregnancy.
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DOI:
10.3390/jcm9113451
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发表时间:
2020-10-27
影响因子:
3.9
通讯作者:
Dunne F
Dunne F
中科院分区:
医学2区
文献类型:
--
作者:
Bogdanet D;O'Shea P;Lyons C;Shafat A;Dunne F

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在全球范围内,妊娠糖尿病(GDM)正在以惊人的速度增长。这种增加与育龄妇女肥胖率的上升有关。由于后续 2 型糖尿病的相关微血管和大血管并发症以及 GDM 对母亲及其婴儿的长期影响,GDM 构成了一个重大的全球健康问题。因此,正确识别受试者是否患有 GDM 至关重要。几十年来,口服葡萄糖耐量试验(OGTT)一直是诊断妊娠糖尿病的主要手段。然而,这个测试有很大的缺陷。在这篇综述中,我们探讨了 OGTT 的历史、其可重复性以及可能影响其结果的许多因素,重点是妊娠。
Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impact on the future health of generations through the long-term impact of GDM on both mothers and their infants. Therefore, correctly identifying subjects as having GDM is of utmost importance. The oral glucose tolerance test (OGTT) has been the mainstay for diagnosing gestational diabetes for decades. However, this test is deeply flawed. In this review, we explore a history of the OGTT, its reproducibility and the many factors that can impact its results with an emphasis on pregnancy.
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