A narrative review of risk factors and interventions for cancer-related cognitive impairment.
A narrative review of risk factors and interventions for cancer-related cognitive impairment.
复制标题
叙述性综述了与癌症相关认知障碍的危险因素和干预措施。
DOI：
10.21037/atm-20-6443
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发表时间：
2021-01
影响因子：
--
通讯作者：
Yu E
中科院分区：
文献类型：
--
作者：
Bai L;Yu E
癌症相关认知损害（Cancer-related cognitive impairment，CRCI）是指非中枢神经系统恶性肿瘤及其相关治疗引起的一系列与脑结构和功能改变相关的认知损害症状。CRCI可能表现为记忆丧失、注意力受损、多任务处理和单词检索困难以及理解速度降低。CRCI已成为影响癌症幸存者生活质量的普遍因素之一。不同的治疗方法，包括手术、化疗、放疗、内分泌治疗和靶向药物，都可能导致CRCI。同时，患者的因素，包括情感挑战和基因组成，也有助于CRCI的发展。可以使用兴奋剂哌甲酯和莫达非尼、尼古丁的代谢产物可替宁、抗抑郁药氟西汀和氟伏沙明、痴呆药物多奈哌齐、抗氧化剂硫酸锌、n-乙酰半胱氨酸、丙泊酚和中药银叶药来治疗该病症。心理治疗，包括冥想和放松，认知康复训练，沿着物理治疗，包括有氧运动，阻力训练，平衡训练，瑜伽，气功，太极脑电图生物反馈和针灸，也有利于缓解癌症相关的认知障碍症状。近年来，研究人员一直关注与病情相关的因素和可用的干预措施。然而，大多数研究都是独立进行的，目前还没有任何综述总结了最新的研究结果。本文综述了CRCI的相关因素和潜在治疗方法的现状。我们还提供具体的建议，以促进未来的研究和整合在这一领域。
Cancer-related cognitive impairment (CRCI) refers to a series of cognitive impairment symptoms associated with alternations in brain structure and function, caused by a non-central nervous system malignant tumor and its related treatment. CRCI may present as memory loss, impaired concentration, difficulty in multitasking and word retrieval, and reduced comprehension speed. CRCI has become one of the prevalent factors that compromise the quality of life for cancer survivors. Different treatments, including surgery, chemotherapy, radiotherapy, endocrine therapy, and targeted drugs, may contribute to CRCI. Meanwhile, patients’ factors, including emotional challenges and genetic makeup, also contribute to the development of CRCI. The condition can be treated with using stimulants methylphenidate and modafinil, metabolites of nicotine: cotinine, antidepressants of fluoxetine and fluvoxamine, dementia drug of donepezil, and antioxidants ZnSO4, n-acetyl cysteine, propofol, and Chinese herbal of silver leaf medicine. Psychotherapies, including meditation and relaxation, cognitive rehabilitation training, along with physical therapies, including aerobic exercise, resistance training, balance training, yoga, qigong, tai chi electroencephalogram biofeedback, and acupuncture, are also beneficial in alleviating cancer-related cognitive impairment symptoms. In recent years, researchers have focused on factors related to the condition and on the available interventions. However, most research was conducted independently, and no review has yet summarized the latest findings. This review details and discusses the status of related factors and potential treatments for CRCI. We also supply specific recommendations to facilitate future research and integration in this field.
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