Photoactivation switch from type II to type I reactions by electron-rich micelles for improved photodynamic therapy of cancer cells under hypoxia.
Photoactivation switch from type II to type I reactions by electron-rich micelles for improved photodynamic therapy of cancer cells under hypoxia.
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DOI：
10.1016/j.jconrel.2011.08.019
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发表时间：
2011-12-20
期刊：
影响因子：
--
通讯作者：
Gao J
中科院分区：
文献类型：
--
作者：
Ding H;Yu H;Dong Y;Tian R;Huang G;Boothman DA;Sumer BD;Gao J
光动力疗法（PDT）是一种新兴的用于治疗多种疾病的临床模式。大多数光敏剂是疏水性的，难溶于水。许多新的纳米平台已经成功建立，以提高PS药物的递送效率。然而，很少有报道的研究已经调查了载体微环境如何可能影响PS药物的生物物理性质，并随后影响其在杀死恶性细胞中的生物学功效。在这项研究中，我们描述了调制的I型和II型光敏剂，5，10，15，20-四（meso-hydroxyphenyl）卟啉（mTHPP）的光活化过程，胶束核心环境。富电子的聚甲基丙烯酸2-（二异丙基氨基）乙酯（PDPA）胶束的光活化作用从II型机制增加到I型机制，这显著增加了通过电子转移途径产生的O2·−，而不是通过能量转移过程产生的1 O2。在氩饱和条件下，PDPA胶束在多个癌细胞系中导致比缺电子聚（D，L-丙交酯）对照增强的光毒性。这些数据表明，胶束载体不仅可以提高光敏剂药物的生物利用度，而且还可以调节生物物理性质以提高PDT功效。
Photodynamic therapy (PDT) is an emerging clinical modality for the treatment of a variety of diseases. Most photosensitizers are hydrophobic and poorly soluble in water. Many new nanoplatforms have been successfully established to improve the delivery efficiency of PS drugs. However, few reported studies have investigated how the carrier microenvironment may affect the photophysical properties of PS drugs and subsequently, their biological efficacy in killing malignant cells. In this study, we describe the modulation of type I and II photoactivation processes of the photosensitizer, 5,10,15,20-tetrakis(meso-hydroxyphenyl)porphyrin (mTHPP), by the micelle core environment. Electron-rich poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) micelles increased photoactivations from type II to type I mechanisms, which significantly increased the generation of O2•− through the electron transfer pathway over 1O2 production through energy transfer process. The PDPA micelles led to enhanced phototoxicity over the electron-deficient poly(D,L-lactide) control in multiple cancer cell lines under argon-saturated conditions. These data suggest that micelle carriers may not only improve the bioavailability of photosensitizer drugs, but also modulate photophysical properties for improved PDT efficacy.
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影响因子：
64.8
作者：
MOAN, J;WOLD, E
通讯作者：
WOLD, E
影响因子：
3.6
作者：
Roby, Aruna;Erdogan, Stma;Torchilin, Vladimir P.
通讯作者：
Torchilin, Vladimir P.
影响因子：
3.6
作者：
Rosen, GM;Beselman, A;MacKerell, AD
通讯作者：
MacKerell, AD
影响因子：
3.3
作者：
Milanesio, ME;Alvarez, MG;Durantini, EN
通讯作者：
Durantini, EN
纳米胶束给药改善了原卟啉 IX 的光物理性质和光动力疗法的疗效。
DOI：
10.1016/j.jconrel.2011.01.004
发表时间：
2011-05-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Ding H;Sumer BD;Kessinger CW;Dong Y;Huang G;Boothman DA;Gao J
通讯作者：
Gao J