Postsynaptic signaling during plasticity of dendritic spines.
Postsynaptic signaling during plasticity of dendritic spines.
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DOI：
10.1016/j.tins.2011.12.002
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发表时间：
2012-02
影响因子：
15.9
通讯作者：
Yasuda R
中科院分区：
文献类型：
--
作者：
Murakoshi H;Yasuda R
树突棘是由神经元树突发出的小型球状突触后区室，被认为是记忆存储的基本单位。尽管尺寸很小（约 0.1 飞升），但脊柱中存在数千种蛋白质，包括受体、通道、支架蛋白和信号酶。这些分子介导的生化信号导致树突棘的形态和功能可塑性，并最终导致大脑的学习和记忆。在这里，我们回顾了监测单个树突棘分子事件的成像技术的最新进展所带来的对树突可塑性潜在机制的新见解。每种蛋白质的活性表现出特定的时空模式，协调不同微域的下游事件以改变树突棘的功能和形态。
Dendritic spines, small bulbous postsynaptic compartments emanating from neuronal dendrites, have been thought to serve as basic units of memory storage. Despite their small size (~0.1 femtoliter), thousands of species of proteins exist in the spine, including receptors, channels, scaffolding proteins and signaling enzymes. Biochemical signaling mediated by these molecules leads to morphological and functional plasticity of dendritic spines, and ultimately learning and memory in the brain. Here, we review new insights into the mechanisms underlying spine plasticity brought about by recent advances in imaging techniques to monitor molecular events in single dendritic spines. The activity of each protein displays a specific spatiotemporal pattern, coordinating downstream events at different microdomains to change the function and morphology of dendritic spines.
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