The collateral network concept: remodeling of the arterial collateral network after experimental segmental artery sacrifice.
The collateral network concept: remodeling of the arterial collateral network after experimental segmental artery sacrifice.
复制标题
DOI：
10.1016/j.jtcvs.2010.06.017
复制
发表时间：
2011-04
影响因子：
6
通讯作者：
Griepp, Randall B.
中科院分区：
文献类型：
--
作者：
Etz, Christian D.;Kari, Fabian A.;Mueller, Christoph S.;Brenner, Robert M.;Lin, Hung-Mo;Griepp, Randall B.
预防胸腹主动脉瘤（TAAA）开放手术或腔内修复术后截瘫的综合策略需要全面了解侧支网络（CN）对广泛节段动脉（SA）牺牲的反应。10只约克郡猪接受低粘度丙烯酸树脂灌注。使用心肺转流术，在所有SA处死后立即、6小时、24小时和5天（5天）（T4-L5），分别以自然状态灌注两只动物。消化周围组织后，使用光学和扫描电子显微镜对CN的血管铸型进行动脉和小动脉直径以及血管系统的密度和空间方向的分析。在24小时内，脊髓前动脉（阿萨）的直径显著增加，在5天内，阿萨和硬膜外动脉网的直径扩大了80-100%（p <0.0001）。同样到第5天，肌内棘旁血管的密度增加（p<.0001），观察到小动脉大小分布向大动脉转移（p=.0002），平行于脊髓的小动脉发生显著重新排列（p=.0005）。SA闭塞后5天内，椎管内和椎旁动脉和小动脉发生了深刻的解剖学改变，为通过侧支通路保存脊髓血流提供了解剖学基础。
A comprehensive strategy to prevent paraplegia after open surgical or endovascular repair of thoracoabdominal aortic aneurysms (TAAA) requires a thorough understanding of the response of the collateral network (CN) to extensive segmental artery (SA) sacrifice. 10 Yorkshire pigs underwent perfusion with a low-viscosity acrylic resin. Using cardiopulmonary bypass, two animals each were perfused in the native state, immediately, six hours, 24h and five days (5d) after sacrifice of all SAs (T4-L5). After digestion of surrounding tissue, the vascular cast of the CN underwent analysis of arterial and arteriolar diameters and the density and spatial orientation of the vasculature, using light and scanning electron microscopy. Within 24 hours, the diameter of the anterior spinal artery (ASA) had increased significantly, and within 5 days the ASA and the epidural arterial network had enlarged in diameter by 80-100% (p <.0001). Also by 5 days, the density of the intramuscular paraspinous vessels had increased (p<.0001), a shift of size distribution from small to larger arterioles was seen (p=.0002), and a significant realignment of arterioles parallel to the spinal cord had occurred (p=.0005). Within 5d after SA occlusion, profound anatomical alterations in the intraspinal and paraspinous arteries and arterioles occur, providing the anatomical substrate for preservation of spinal cord blood flow via collateral pathways.
登录
查看更多内容
影响因子：
3.4
作者：
Etz, Christian D.;Homann, Tobias M.;Griepp, Randall B.
通讯作者：
Griepp, Randall B.
DOI：
10.1111/j.1582-4934.2006.tb00290.x
发表时间：
2006-01
影响因子：
5.3
作者：
Heil M;Eitenmüller I;Schmitz-Rixen T;Schaper W
通讯作者：
Schaper W
影响因子：
3.4
作者：
Etz, Christian D.;Homann, Tobias M.;Griepp, Randall B.
通讯作者：
Griepp, Randall B.
影响因子：
19.6
作者：
Wei, W.;Popov, V.;Bello-Reuss, E.
通讯作者：
Bello-Reuss, E.
影响因子：
--
作者：
Verli, Flaviana Dornela;Rossi-Schneider, Tissiana Raquel;de Souza, Antonieta Lopes
通讯作者：
de Souza, Antonieta Lopes