Arteriogenesis versus angiogenesis: similarities and differences.
Arteriogenesis versus angiogenesis: similarities and differences.
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DOI：
10.1111/j.1582-4934.2006.tb00290.x
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发表时间：
2006-01
影响因子：
5.3
通讯作者：
Schaper W
中科院分区：
文献类型：
--
作者：
Heil M;Eitenmüller I;Schmitz-Rixen T;Schaper W
在工业化国家，心血管疾病占75岁以前总死亡率的一半以上。开发促进血管代偿生长的治疗方法可能优于姑息性手术干预。因此，对潜在机制的研究投入了大量的精力。根据最初的触发因素，成人血管的生长主要通过两个过程进行，血管生成和动脉生成。虽然血管生成是由缺氧诱导并产生新的毛细血管，但动脉生成是由物理力诱导的，最重要的是流体剪切应力。因此，在实验条件下，发现长期升高的流体剪切应力是最强的触发因素。动脉生成是指将原有的动脉-小动脉吻合处重塑为完全发育和功能齐全的动脉。在这两个生长过程中，维管壁结构的扩大被现有壁细胞的增殖所覆盖。最近，越来越多的证据表明，循环细胞，尤其是血液单核细胞，在血管生长过程中起着关键作用。由于单核细胞/巨噬细胞释放一种参与血管生长的趋化因子、生长因子和蛋白酶的混合物，它们的作用似乎是旁分泌的。类似的作用目前正在讨论各种群体的骨髓来源的干细胞和内皮祖细胞。相反，最初的假设是，这些细胞在经历（反）分化后，通过结构整合进入生长的血管壁，这一假设日益受到挑战。
Cardiovascular diseases account for more than half of total mortality before the age of 75 in industrialized countries. To develop therapies promoting the compensatory growth of blood vessels could be superior to palliative surgical surgical interventions. Therefore, much effort has been put into investigating underlying mechanisms. Depending on the initial trigger, growth of blood vessels in adult organisms proceeds via two major processes, angiogenesis and arteriogenesis. While angiogenesis is induced by hypoxia and results in new capillaries, arteriogenesis is induced by physical forces, most importantly fluid shear stress. Consequently, chronically elevated fluid shear stress was found to be the strongest trigger under experimental conditions. Arteriogenesis describes the remodelling of pre-existing arterio-arteriolar anastomoses to completely developed and functional arteries. In both growth processes, enlargement of vascular wall structures was proposed to be covered by proliferation of existing wall cells. Recently, increasing evidence emerges, implicating a pivotal role for circulating cells, above all blood monocytes, in vascular growth processes. Since it has been shown that monocytes/macrophage release a cocktail of chemokines, growth factors and proteases involved in vascular growth, their contribution seems to be of a paracrine fashion. A similar role is currently discussed for various populations of bone-marrow derived stem cells and endothelial progenitors. In contrast, the initial hypothesis that these cells -after undergoing a (trans-)differentiation- contribute by a structural integration into the growing vessel wall, is increasingly challenged.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
DOI：
10.1152/ajpheart.00478.2002
发表时间：
2003-01-01
影响因子：
4.8
作者：
Cai, WJ;Koltai, S;Schaper, J
通讯作者：
Schaper, J
影响因子：
20.1
作者：
Deindl, E;Buschmann, I;Schaper, W
通讯作者：
Schaper, W
影响因子：
15.9
作者：
Gimbrone, MA;Nagel, T;Topper, JN
通讯作者：
Topper, JN
影响因子：
20.1
作者：
Heil, M;Ziegelhoeffer, T;Schaper, W
通讯作者：
Schaper, W