Early T cell differentiated chronic myeloid leukemia blast crisis with rearrangement of the breakpoint cluster region but not of the T cell receptor beta chain genes.
Early T cell differentiated chronic myeloid leukemia blast crisis with rearrangement of the breakpoint cluster region but not of the T cell receptor beta chain genes.
复制标题
早期 T 细胞分化为慢性粒细胞白血病急变，伴有断点簇区域重排，但 T 细胞受体 β 链基因未重排。
作者：
M. Gramatzki;C. Bartram;D. Müller;M. Walter;H. Tittelbach;J. Kalden
早期T细胞分化是描述在费城染色体阳性慢性粒细胞白血病（CML）在急变的情况下，支持CML前体细胞的多谱系分化潜力。在缺乏髓系标志物的情况下，末端脱氧核苷酸转移酶（TdT）的强阳性和与T细胞抗体3A1的反应性，但缺乏更成熟的T细胞抗原，为未成熟T细胞分化提供了证据。22号染色体断裂点簇区（bcr）的分子分析显示重排，从而证实了早期T细胞母细胞的CML起源。T细胞受体β链序列在生殖系构型中发现，因此表明CML原始细胞中T细胞分化的非常不成熟阶段。
Early T cell differentiation is described in a case of Philadelphia chromosome-positive chronic myeloid leukemia (CML) in blast crisis, supporting multi-lineage differentiation potential of CML precursor cells. In the absence of myeloid markers, strong positivity for terminal deoxynucleotidyl transferase (TdT) and reactivity with T cell antibody 3A1, but lack of more mature T cell antigens, provided evidence for immature T cell differentiation. Molecular analysis of the breakpoint cluster region (bcr) in chromosome 22 revealed a rearrangement and thus confirmed the CML origin of the early T cell blasts. T cell receptor beta chain sequences were found in germline configuration and therefore suggest a very immature stage of T cell differentiation in the CML blasts.
DOI：
10.1073/pnas.83.6.1807
发表时间：
1986-03
影响因子：
11.1
作者：
J. Erikson;Constance A. GRIFFINt;A. Ar-rushdi;M. Valtieri;James Hoxiem;Janet FINANt;Beverly S. EMANUELt-Beverly-S
通讯作者：
J. Erikson;Constance A. GRIFFINt;A. Ar-rushdi;M. Valtieri;James Hoxiem;Janet FINANt;Beverly S. EMANUELt-Beverly-S
B 和 T 淋巴细胞谱系参与慢性粒细胞白血病的发生率。
影响因子：
20.3
作者：
Nitta,M;Kato,Y;Strife,A;Wachter,M;Fried,J;Perez,A;Jhanwar,S;Duigou-Osterndorf,R;Chaganti,RS;Clarkson,B
通讯作者：
Clarkson,B