Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level.
Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level.
复制标题
垃圾谈话：转录级别的哺乳动物蛋白酶体调节。
DOI：
10.1016/j.tig.2020.09.005
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Radhakrishnan SK
中科院分区：
文献类型：
--
作者：
Kamber Kaya HE;Radhakrishnan SK
健康哺乳动物细胞的关键在于被称为蛋白酶体的蛋白水解机器的正常运作。蛋白酶体是多亚基复合物，其催化不需要的蛋白质的降解，并且还控制关键细胞调节因子的半衰期。异常的蛋白酶体活性通常与癌症和神经退行性变等人类疾病有关，因此深入了解其如何调节对潜在的疾病干预具有重要意义。蛋白酶体的转录调控可以决定其丰度，也影响其功能，组装和位置。这确保了适当的蛋白酶体活性，以响应发育线索和生理条件，如饥饿和氧化应激。在这篇综述中，我们强调和讨论的转录因子参与哺乳动物蛋白酶体的调节的作用。
The key to a healthy mammalian cell lies in properly functioning proteolytic machineries called proteasomes. The proteasomes are multi-subunit complexes that catalyze the degradation of unwanted proteins and also control half-lives of key cellular regulatory factors. Aberrant proteasome activity is often associated with human diseases such as cancer and neurodegeneration, and so an in-depth understanding of how it is regulated has implications for potential disease interventions. Transcriptional regulation of the proteasome can dictate its abundance and also influence its function, assembly and location. This ensures proper proteasomal activity in response to developmental cues and to physiological conditions such as starvation and oxidative stress. In this review, we highlight and discuss the roles of the transcription factors that are involved in the regulation of the mammalian proteasome.
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