IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.
IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.
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DOI：
10.1002/eji.201041037
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发表时间：
2010-12
影响因子：
5.4
通讯作者：
Vosshenrich, Christian A. J.
中科院分区：
文献类型：
--
作者：
Elkabets, Moshe;Ribeiro, Vera S. G.;Dinarello, Charles A.;Ostrand-Rosenberg, Suzanne;Di Santo, James P.;Apte, Ron N.;Vosshenrich, Christian A. J.
慢性炎症与促进恶性肿瘤和肿瘤进展相关。许多肿瘤增强骨髓源性抑制细胞（MDSC）的积累，其通过抑制抗肿瘤免疫应答而促进肿瘤进展和生长。已显示分泌到肿瘤微环境中的肿瘤来源的IL-1β诱导具有增强的抑制T细胞的能力的MDSC的积累。在这项研究中，我们发现IL-1β诱导的MDSC的增强的抑制潜力是由于缺乏Ly 6C表达的MDSC的新子集的活性。在不存在IL-1β诱导的炎症的情况下，该亚群在荷瘤小鼠中以低频率存在;然而，在炎症条件下，Ly 6Cneg MDSC占主导地位。Ly 6Cneg MDSC在体外和体内损害NK细胞发育和功能。这些结果鉴定了具有独特功能特性的新型IL-1β诱导的MDSC亚群。因此，Ly 6Cneg MDSC介导NK细胞抑制可能代表治疗干预的有用靶标。
Chronic inflammation is associated with promotion of malignancy and tumor progression. Many tumors enhance the accumulation of myeloid-derived suppressor cells (MDSC), which contribute to tumor progression and growth by suppressing anti-tumor immune responses. Tumor-derived IL-1β secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC possessing an enhanced capacity to suppress T cells. In this study, we found that the enhanced suppressive potential of IL-1β-induced MDSC was due to the activity of a novel subset of MDSC lacking Ly6C expression. This subset was present at low frequency in tumor-bearing mice in the absence of IL-1β-induced inflammation; however, under inflammatory conditions Ly6Cneg MDSC were predominant. Ly6Cneg MDSC impaired NK cell development and functions in vitro and in vivo. These results identify a novel IL-1β-induced subset of MDSC with unique functional properties. Ly6Cneg MDSC mediating NK cell suppression may thus represent useful targets for therapeutic interventions.
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DOI：
10.4049/jimmunol.1000901
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lechner MG;Liebertz DJ;Epstein AL
通讯作者：
Epstein AL
影响因子：
5.5
作者：
Bunt, Stephanie K.;Clements, Virginia K.;Ostrand-Rosenberg, Suzanne
通讯作者：
Ostrand-Rosenberg, Suzanne
癌症扩增的骨髓源性抑制细胞通过膜结合 TGF-β1 诱导 NK 细胞无反应。
影响因子：
4.4
作者：
Li, Hequan;Han, Yanmei;Cao, Xuetao
通讯作者：
Cao, Xuetao
影响因子：
20.3
作者：
Movahedi, Kiavash;Guilliams, Martin;Van Ginderachter, Jo A.
通讯作者：
Van Ginderachter, Jo A.
影响因子：
5.4
作者：
De Colvenaer, Veerle;Taveirne, Sylvie;Leclercq, Georges
通讯作者：
Leclercq, Georges