Trehalose-6-phosphate and SnRK1 kinases in plant development and signaling: the emerging picture.
Trehalose-6-phosphate and SnRK1 kinases in plant development and signaling: the emerging picture.
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DOI：
10.3389/fpls.2014.00119
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发表时间：
2014
影响因子：
5.6
通讯作者：
Gazzarrini S
中科院分区：
文献类型：
--
作者：
Tsai AY;Gazzarrini S
碳水化合物或糖通过调节细胞分裂和扩张来调节植物生长的各个方面。除了作为生长的能量来源和细胞的结构成分发挥重要作用外，碳水化合物还调节发育程序表达的时间。二糖海藻糖被用作能量来源，作为葡萄糖的储存和运输分子，以及在所有界中作为对应激期间的细胞保护重要的应激响应化合物。然而，海藻糖在大多数植物中的含量非常低，这表明这种非还原性二糖的代谢作用是信号传导。在过去的十年中，海藻糖-6-磷酸（T6 P），海藻糖代谢的中间体，已被证明是调节胚胎和营养体发育，开花时间，分生组织的确定性，和细胞命运的规范在植物中。T6 P作为一种代谢和转录的全局调节因子，促进植物生长，并响应糖的可用性触发发育阶段的转变。蔗糖非发酵相关激酶1（SnRK 1）家族的成员是T6 P的靶点之一，其是能量可用性的传感器，并在代谢胁迫期间抑制植物生长和发育以维持能量稳态。在这篇综述中，我们将讨论糖代谢产物T6 P和SnRK 1激酶在响应碳水化合物水平的发育阶段转换的调节中的相反作用。我们将专注于如何这两个全球性的代谢过程的调节器整合环境的线索，并与激素信号通路相互作用，以调节植物的发展。
Carbohydrates, or sugars, regulate various aspects of plant growth through modulation of cell division and expansion. Besides playing essential roles as sources of energy for growth and as structural components of cells, carbohydrates also regulate the timing of expression of developmental programs. The disaccharide trehalose is used as an energy source, as a storage and transport molecule for glucose, and as a stress-responsive compound important for cellular protection during stress in all kingdoms. Trehalose, however, is found in very low amounts in most plants, pointing to a signaling over metabolic role for this non-reducing disaccharide. In the last decade, trehalose-6-phosphate (T6P), an intermediate in trehalose metabolism, has been shown to regulate embryonic and vegetative development, flowering time, meristem determinacy, and cell fate specification in plants. T6P acts as a global regulator of metabolism and transcription promoting plant growth and triggering developmental phase transitions in response to sugar availability. Among the T6P targets are members of the Sucrose-non-fermenting1-related kinase1 (SnRK1) family, which are sensors of energy availability and inhibit plant growth and development during metabolic stress to maintain energy homeostasis. In this review, we will discuss the opposite roles of the sugar metabolite T6P and the SnRK1 kinases in the regulation of developmental phase transitions in response to carbohydrate levels. We will focus on how these two global regulators of metabolic processes integrate environmental cues and interact with hormonal signaling pathways to modulate plant development.
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DOI：
10.1152/physiol.00010.2011
发表时间：
2011-08
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Cantó C;Auwerx J
通讯作者：
Auwerx J
影响因子：
16
作者：
Banko, Max R.;Allen, Jasmina J.;Schaffer, Bethany E.;Wilker, Erik W.;Tsou, Peiling;White, Jamie L.;Villen, Judit;Wang, Beatrice;Kim, Sara R.;Sakamoto, Kei;Gygi, Steven P.;Cantley, Lewis C.;Yaffe, Michael B.;Shokat, Kevan M.;Brunet, Anne
通讯作者：
Brunet, Anne
影响因子：
5.6
作者：
Dobrenel T;Marchive C;Azzopardi M;Clément G;Moreau M;Sormani R;Robaglia C;Meyer C
通讯作者：
Meyer C
影响因子：
4.3
作者：
Corbesier, L;Lejeune, P;Bernier, G
通讯作者：
Bernier, G
影响因子：
7.4
作者：
Curaba, J;Moritz, T;Vachon, G
通讯作者：
Vachon, G