Alarmins and immunity.

Alarmins and immunity.
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DOI:
10.1111/imr.12577
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发表时间:
2017-11
影响因子:
8.7
通讯作者:
Oppenheim JJ
Oppenheim JJ
中科院分区:
医学1区
文献类型:
--
作者:
Yang D;Han Z;Oppenheim JJ

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自“警报”假说概念化以来,已经过去了十多年。alarmin家族在数量和概念上都在不断扩大。近年来,alarmins在宿主防御、基因表达调控、细胞内环境稳定、创伤愈合、炎症、变态反应、自身免疫和肿瘤发生等多种生理和病理生理过程中作为启动者和参与者发挥着重要作用。在这里,我们提供了一个一般性的看法alarmins参与诱导先天性和适应性免疫反应,以及它们对肿瘤免疫的贡献。
More than a decade has passed since the conceptualization of the ‘alarmin’ hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participarnts in a diverse range of physiological and pathophysiological processes such as host defense, regulation of gene expression, cellular homeostasis, wound healing, inflammation, allergy, autoimmunity, and oncogenesis. Here we provide a general view on the participation of alarmins in the induction of innate and adaptive immune responses, as well as their contribution to tumor immunity.
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