Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study.
Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study.
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淋巴细胞减少症可预测 COVID-19 患者的疾病严重程度和康复情况：一项单中心回顾性研究。
DOI：
10.1371/journal.pone.0241659
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Zhang G
中科院分区：
文献类型：
--
作者：
Liu J;Li H;Luo M;Liu J;Wu L;Lin X;Li R;Wang Z;Zhong H;Zheng W;Zhou Y;Jiang D;Tan X;Zhou Z;Peng H;Zhang G
The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of lymphopenia on disease severity. A total of 115 patients with confirmed COVID-19 from a tertiary hospital in Changsha, China, were enrolled. Clinical, laboratory, treatment and outcome data were gathered and compared between patients with and without lymphopenia. The median age was 42 years (1–75). Fifty-four patients (47.0%) of the 115 patients had lymphopenia on admission. More patients in the lymphopenia group had hypertension (30.8% vs. 10.0%, P = 0.006) and coronary heart disease (3.6% vs. 0%, P = 0.029) than in the nonlymphopenia group, and more patients with leukopenia (48.1% vs 14.8%, P<0.001) and eosinopenia (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia was also correlated with severity grades of pneumonia (P<0.001) and C-reactive protein (CRP) level (P = 0.0014). Lymphopenia was associated with a prolonged duration of hospitalization (17.0 days vs. 14.0 days, P = 0.002). Lymphocyte recovery appeared the earliest, prior to CRP and chest radiographs, in severe cases, which suggests its predictive value for disease improvement. Our results demonstrated the clinical significance of lymphopenia for predicting the severity of and recovery from COVID-19, which emphasizes the need to dynamically monitor lymphocyte count.
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影响因子：
64.8
作者：
Li W;Moore MJ;Vasilieva N;Sui J;Wong SK;Berne MA;Somasundaran M;Sullivan JL;Luzuriaga K;Greenough TC;Choe H;Farzan M
通讯作者：
Farzan M
DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
DOI：
10.1016/j.ijid.2004.07.014
发表时间：
2005-11
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
He Z;Zhao C;Dong Q;Zhuang H;Song S;Peng G;Dwyer DE
通讯作者：
Dwyer DE
DOI：
10.1016/s1726-4901(09)70231-x
发表时间：
2005-03
期刊：
Journal of the Chinese Medical Association : JCMA
影响因子：
--
作者：
Liu CY;Huang LJ;Lai CH;Chen HP;Chen TL;Fung CP;Liu CY
通讯作者：
Liu CY
影响因子：
6.1
作者：
Liu, Kui;Fang, Yuan-Yuan;Liu, Hui-Guo
通讯作者：
Liu, Hui-Guo