Differentiating Dynamic Cerebral Autoregulation Across Vascular Territories.
Differentiating Dynamic Cerebral Autoregulation Across Vascular Territories.
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DOI：
10.3389/fneur.2021.653167
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发表时间：
2021
影响因子：
3.4
通讯作者：
Favilla CG
中科院分区：
文献类型：
--
作者：
Reehal N;Cummings S;Mullen MT;Baker WB;Kung D;Tackett W;Favilla CG
目的：经颅多普勒通常用于计算大脑自动调节，但测量通常限于单个脑动脉。在探索地形异质性，这项研究报告的第一次彻底比较所有主要脑血管的自动调节。研究方法：在40名健康成人中，监测大脑前、中、后动脉的血流速度，并与动脉血压同步。传递函数分析通过量化血压和脑血流速度之间的关系提供了自动调节的特征。结果：相位，量化自动调节的时间过程，在所有血管中是相似的。定量血流动力学调节幅度的增益在大脑后动脉中较低，表明调节更紧密。然而，在调整每个血管区域的基线血流差异后，所有血管的归一化增益相似。结论：用经颅多普勒方法区分脑血管区域之间的动态脑自动调节是可行的。在健康志愿者的大脑后动脉中，绝对流量受到更严格的调节，但相对流量调节在整个脑血管区域是一致的。重要性：该方法可应用于局灶性疾病状态，如中风或可逆性后部脑病综合征，其中自动调节的地形分布可能是特别关键的。
Objective: Transcranial Doppler is commonly used to calculate cerebral autoregulation, but measurements are typically restricted to a single cerebral artery. In exploring topographic heterogeneity, this study reports the first thorough comparison of autoregulation in all major cerebral vessels. Methods: In forty healthy adults, flow velocity was monitored in the anterior, middle, and posterior cerebral arteries, and synchronized with arterial blood pressure. A transfer function analysis provided characteristics of autoregulation by quantifying the relationship between blood pressure and cerebral blood flow velocity. Results: Phase, which quantifies the time course of autoregulation, was similar in all vessels. Gain, which quantifies the magnitude of hemodynamic regulation, was lower in posterior cerebral artery, indicative of tighter regulation. However, after adjusting for baseline flow differences in each vascular territory, normalized gain was similar in all vessels. Conclusions: Discriminating dynamic cerebral autoregulation between cerebrovascular territories is feasible with a transcranial doppler based approach. In the posterior cerebral artery of healthy volunteers, absolute flow is more tightly regulated, but relative flow regulation is consistent across cerebrovascular territories. Significance: The methodology can be applied to focal disease states such as stroke or posterior reversible encephalopathy syndrome, in which the topographic distribution of autoregulation may be particularly critical.
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影响因子：
2.4
作者：
Schmidt, EA;Piechnik, SK;Czosnyka, M
通讯作者：
Czosnyka, M
DOI：
10.1097/00004647-200008000-00011
发表时间：
2000-08-01
影响因子：
6.3
作者：
Ito, H;Yokoyama, I;Kanno, I
通讯作者：
Kanno, I
DOI：
10.1152/ajpheart.00328.2012
发表时间：
2012-09-01
影响因子：
4.8
作者：
Tzeng, Y. C.;Ainslie, P. N.;Rickards, C. A.
通讯作者：
Rickards, C. A.
DOI：
10.1093/gerona/60.11.1484
发表时间：
2005-11-01
影响因子：
5.1
作者：
Sorond, FA;Khavari, R;Lipsitz, LA
通讯作者：
Lipsitz, LA
影响因子：
8.3
作者：
AASLID, R;LINDEGAARD, KF;NORNES, H
通讯作者：
NORNES, H