Potassium ion movement in the inner ear: insights from genetic disease and mouse models.
Potassium ion movement in the inner ear: insights from genetic disease and mouse models.
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DOI：
10.1152/physiol.00018.2009
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Jentsch TJ
中科院分区：
文献类型：
--
作者：
Zdebik AA;Wangemann P;Jentsch TJ
耳蜗和前庭迷路的感觉转导依赖于使机械敏感毛细胞的毛束偏转的流体运动。毛细胞静纤毛尖端的机械敏感换能器通道允许 K+ 流入细胞。这种不寻常的过程依赖于内耳特有的离子梯度。将基因与人类和小鼠的耳聋联系起来有助于确定对听力和平衡至关重要的离子传输机制。对患者进行形态学分析很困难，但小鼠模型有助于研究不同发育时间点的表型。本综述重点关注血管纹中的细胞离子传输机制，该机制为感觉转导产生主要的电化学梯度。
Sensory transduction in the cochlea and vestibular labyrinth depends on fluid movements that deflect the hair bundles of mechanosensitive hair cells. Mechanosensitive transducer channels at the tip of the hair cell stereocilia allow K+ to flow into cells. This unusual process relies on ionic gradients unique to the inner ear. Linking genes to deafness in humans and mice has been instrumental in identifying the ion transport machinery important for hearing and balance. Morphological analysis is difficult in patients, but mouse models have helped to investigate phenotypes at different developmental time points. This review focuses on cellular ion transport mechanisms in the stria vascularis that generate the major electrochemical gradients for sensory transduction.
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