Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence.
Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence.
复制标题
DOI：
10.1016/j.biopsych.2008.07.029
复制
发表时间：
2008-12-15
影响因子：
10.6
通讯作者：
Krystal, John H.
中科院分区：
文献类型：
--
作者：
Driesen, Naomi R.;Leung, Hoi-Chung;Calhoun, Vincent D.;Constable, R. Todd;Gueorguieva, Ralitza;Hoffman, Ralph;Skudlarski, Pawel;Goldman-Rakic, Patricia S.;Krystal, John H.
关键词：
比较健康受试者和精神分裂症患者在工作记忆特定阶段的前额叶皮质活动，可能有助于确定导致与精神分裂症相关的认知障碍的皮质功能特定阶段的缺陷。这项研究的特点是空间工作记忆任务，类似于在非人类灵长类动物中使用的任务，旨在便于将大脑激活分为编码、维持和反应阶段。14名精神分裂症患者(4名未服用药物)和12名健康对照参与者完成了功能磁共振成像，同时执行了两个水平的记忆负荷的空间工作记忆任务。患者和健康受试者的任务准确性相似。然而，患者在维持和反应阶段表现出大脑激活的减少，但在编码阶段没有。在工作记忆的维持阶段，前额叶活动的减少是由于患者的前额叶活动随着时间的推移而衰退的速度更快。此外，在患者中，而不是在健康受试者中，工作记忆维持期间前额叶活动随时间的减少与记忆任务中较差的表现相关。患者的皮质缺陷似乎与抗精神病药物治疗无关。总体而言，这些数据突显了对工作记忆维持和反应阶段的不同神经生物学的基础研究见解，对于理解精神分裂症认知障碍的神经生物学和推进其治疗具有潜在的重要意义。
Comparing prefrontal cortical activity during particular phases of working memory in healthy subjects and individuals diagnosed with schizophrenia may help to define the phase-specific deficits in cortical function that contribute to cognitive impairments associated with schizophrenia. This study featured a spatial working memory task, similar to that used in non-human primates, that was designed to facilitate separating brain activation into encoding, maintenance and response phases. Fourteen patients with schizophrenia (4 medication-free) and twelve healthy comparison participants completed functional magnetic resonance imaging while performing a spatial working memory task with two levels of memory load. Task accuracy was similar in patients and healthy participants. However, patients showed reductions in brain activation during maintenance and response phases, but not during the encoding phase. The reduced prefrontal activity during the maintenance phase of working memory was attributed to a greater rate of decay of prefrontal activity over time in patients. Also, in patients, but not in healthy subjects, the time-dependent reduction in prefrontal activity during working memory maintenance correlated with poorer performance on the memory task. Cortical deficits in patients did not appear to be related to antipsychotic treatment. Overall, these data highlight that basic research insights into the distinct neurobiologies of the maintenance and response phases of working memory are of potential importance for understanding the neurobiology of cognitive impairment in schizophrenia and advancing its treatment.
登录
查看更多内容
影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
56.9
作者：
FUSTER, JM;ALEXANDER, GE
通讯作者：
ALEXANDER, GE
影响因子：
7.6
作者：
Callicott, JH;Ramsey, NF;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
2.5
作者：
FUNAHASHI, S;BRUCE, CJ;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
影响因子：
3.4
作者：
Krystal, JH;D'Souza, DC;Hoffman, R
通讯作者：
Hoffman, R