A platelet-mimicking theranostic platform for cancer interstitial brachytherapy.
A platelet-mimicking theranostic platform for cancer interstitial brachytherapy.
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作者：
Lyu M;Chen M;Liu L;Zhu D;Wu X;Li Y;Rao L;Bao Z
理由：组织间近距离放射治疗（BT）是一种很有前途的放射治疗癌症，但BT的疗效受到肿瘤放射抗性的限制。材料科学和纳米技术的最新进展为BT提供了许多新的机会。方法：在这项工作中，我们开发了一种仿生纳米治疗诊断平台，用于增强BT。制备了核壳结构的Au@AuPd纳米球（CANS），并将其包裹在血小板（PLT）质膜中。结果如下：由于PLT膜涂层的靶向能力，所得PLT/CANS纳米颗粒有效地逃避免疫清除并特异性地在肿瘤组织中积累。在内窥镜引导下，操作BT针向原位结肠肿瘤提供适当的辐射剂量，同时保留周围器官。累积的PLT/CANS促进了肿瘤组织中的辐射剂量沉积，同时通过催化内源性H2O2产生O2来缓解肿瘤缺氧。经PLT/CANS和BT治疗后，100%的小鼠存活30天。结论：我们的工作提出了一种安全、稳健和有效的策略，用于在适用于腔内和不可切除肿瘤的治疗时增强BT结局。
Rational: Interstitial brachytherapy (BT) is a promising radiation therapy for cancer; however, the efficacy of BT is limited by tumor radioresistance. Recent advances in materials science and nanotechnology have offered many new opportunities for BT. Methods: In this work, we developed a biomimetic nanotheranostic platform for enhanced BT. Core-shell Au@AuPd nanospheres (CANS) were synthesized and then encapsulated in platelet (PLT)-derived plasma membranes. Results: The resulting PLT/CANS nanoparticles efficiently evaded immune clearance and specifically accumulated in tumor tissues due to the targeting capabilities of the PLT membrane coating. Under endoscopic guidance, a BT needle was manipulated to deliver appropriate radiation doses to orthotopic colon tumors while sparing surrounding organs. Accumulated PLT/CANS enhanced the irradiation dose deposition in tumor tissue while alleviating tumor hypoxia by catalyzing endogenous H2O2 to produce O2. After treatment with PLT/CANS and BT, 100% of mice survived for 30 days. Conclusions: Our work presents a safe, robust, and efficient strategy for enhancing BT outcomes when adapted to treatment of intracavitary and unresectable tumors.
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影响因子：
5.7
作者：
MOERLAND, MA;VANDENBERGH, ACM;BATTERMANN, JJ
通讯作者：
BATTERMANN, JJ
影响因子：
--
作者：
Chen, Shuo;Jiang, Shun-feng;Jiang, Hong
通讯作者：
Jiang, Hong
影响因子：
14
作者：
Deng, Junjie;Xu, Shandong;Su, Ming
通讯作者：
Su, Ming
DOI：
10.1016/j.ijrobp.2009.03.010
发表时间：
2010-03-15
影响因子：
7
作者：
Bruheim, Kjersti;Guren, Marianne G.;Tveit, Kjell Magne
通讯作者：
Tveit, Kjell Magne
影响因子：
10.3
作者：
Murphy, Caitlin C.;Harlan, Linda C.;Geiger, Ann M.
通讯作者：
Geiger, Ann M.