Antibodies to the three major glycoproteins of varicella-zoster virus: search for the relevant host immune response.
Antibodies to the three major glycoproteins of varicella-zoster virus: search for the relevant host immune response.
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水痘带状疱疹病毒三大糖蛋白的抗体：寻找相关的宿主免疫反应。
DOI：
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发表时间：
1987
影响因子：
6.4
通讯作者：
R. Ellis
中科院分区：
文献类型：
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作者：
P. Brunell;V. Novelli;P. Keller;R. Ellis
水痘的临床表现发生在已知接种水痘疫苗后血清转化的个体中。为了确定这些“突破”是否可能是由于缺乏特异性抗体，我们检测了接种水痘疫苗者在接触水痘之前或接触水痘时的血清中水痘-带状疱疹病毒（VZV）三种主要糖蛋白的抗体。这种保护与这些抗体的存在或水平无关。带状疱疹发病前的糖蛋白抗体水平与以前患过水痘但在家庭接触后未患水痘的个体血清中的抗体水平相似。因此，对VZV感染的保护不能用糖蛋白特异性抗体的存在来解释。
Clinical manifestations of chickenpox have occurred in individuals known to have seroconverted after vaccination against varicella. To determine whether these "breakthroughs" might be due to the absence of specific antibodies, we tested sera from vaccinees before or at the time of exposure to varicella for antibodies to the three major glycoproteins of varicella-zoster virus (VZV). Protection could not be correlated with the presence or level of any of these antibodies. Levels of antibodies to glycoproteins before onset of zoster were similar to those in sera of individuals who had had varicella previously and did not develop varicella after household exposure. Thus, protection against infections with VZV cannot be explained by the presence of specific antibodies to glycoproteins.
婴儿期和幼儿期获得的水痘感染的免疫学和流行病学方面。
DOI：
10.1016/s0022-3476(82)80505-2
发表时间：
1982
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Baba,K;Yabuuchi,H;Takahashi,M;Ogra,PL
通讯作者：
Ogra,PL